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同侧快速皮质脊髓通路无法解释中风后的恢复情况。

Ipsilateral fast corticospinal pathways do not account for recovery in stroke.

作者信息

Palmer E, Ashby P, Hajek V E

机构信息

Playfair Neuroscience Unit, University of Toronto, Toronto Western Hospital, Canada.

出版信息

Ann Neurol. 1992 Oct;32(4):519-25. doi: 10.1002/ana.410320407.

DOI:10.1002/ana.410320407
PMID:1456736
Abstract

We tested the hypothesis that in adult humans, recovery from stroke results from the emergence of ipsilateral, fast-conducting corticospinal pathways. In 10 patients recovering from stroke, the unaffected hemisphere was stimulated with an electromagnet and changes in the firing probability of single biceps motor units were used to derive postsynaptic potentials in single biceps motoneurons. Stimuli sufficient to excite the neurons of the fast-conducting corticospinal pathway (as shown by short-latency facilitation of contralateral biceps motoneurons) did not produce short-latency depolarization of ipsilateral biceps motoneurons. The hypothesis is therefore not supported.

摘要

我们验证了这样一个假设

在成年人类中,中风后的恢复源于同侧快速传导的皮质脊髓通路的出现。在10名中风康复患者中,用电磁铁刺激未受影响的半球,并利用肱二头肌单运动单位放电概率的变化来推导肱二头肌单运动神经元的突触后电位。足以激发快速传导皮质脊髓通路神经元的刺激(如对侧肱二头肌运动神经元的短潜伏期易化所示)并未引起同侧肱二头肌运动神经元的短潜伏期去极化。因此,该假设不成立。

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