Radcliffe J, Packer R J, Atkins T E, Bunin G R, Schut L, Goldwein J W, Sutton L N
Division of Child Development and Rehabilitation, Children's Hospital of Philadelphia, Medical School, University of Pennsylvania.
Ann Neurol. 1992 Oct;32(4):551-4. doi: 10.1002/ana.410320411.
Cognitive function and school achievement were studied prospectively over 3 to 4 years in 19 children treated for brain tumors with whole-brain radiotherapy; 14 of 19 also received adjuvant chemotherapy. For the group as a whole, mean IQ fell from a baseline of 104 to 92 at follow-up (p < 0.01). Age was inversely correlated with change in IQ over time (r = 0.71; p < 0.001). Children younger than 7 years at diagnosis had a mean IQ loss of 27 points, while children over 7 years at diagnosis showed no significant decrease in IQ. Decline in IQ occurred between baseline and year 2 of follow-up; none could be documented between years 2 and 4. All children younger than 7 years at diagnosis were receiving special education at follow-up; 50% of the children over 7 years at diagnosis were receiving supplemental educational services.
对19名接受全脑放疗治疗脑肿瘤的儿童进行了为期3至4年的前瞻性认知功能和学业成绩研究；19名儿童中有14名还接受了辅助化疗。对于整个研究组，随访时平均智商从基线的104降至92（p<0.01）。年龄与随时间变化的智商呈负相关（r = 0.71；p<0.001）。诊断时年龄小于7岁的儿童平均智商损失27分，而诊断时年龄大于7岁的儿童智商无显著下降。智商下降发生在基线和随访的第2年之间；在第2年和第4年之间未发现智商下降。所有诊断时年龄小于7岁的儿童在随访时都接受特殊教育；诊断时年龄大于7岁的儿童中有50%接受补充教育服务。
