Duffner P K, Cohen M E, Parker M S
Department of Neurology, State University of New York, Buffalo.
Ann Neurol. 1988 Jun;23(6):575-9. doi: 10.1002/ana.410230608.
Sixteen children with brain tumors received prospective intellectual evaluations with a follow-up of 2 to 5 years. All patients were treated with surgery and radiation and 5 received chemotherapy. Most of the children remained within the normal range of intelligence, but intelligence quotient (IQ) scores declined over time. Learning disabilities were present in 15 of 16 children after radiation, and 11 required special educational services. Risk factors associated with decline in IQ appear to be young age at time of radiation and adjuvant chemotherapy.
16名患有脑肿瘤的儿童接受了前瞻性智力评估，随访时间为2至5年。所有患者均接受了手术和放疗，5名接受了化疗。大多数儿童的智力仍保持在正常范围内，但智商（IQ）分数随时间下降。放疗后16名儿童中有15名存在学习障碍，11名需要特殊教育服务。与智商下降相关的风险因素似乎是放疗时年龄较小和辅助化疗。
