Parsanezhad Mohammad Ebrahim, Lahsaee Masoud, Alborzi Saeed, Vafaei Homayra, Schmidt Ernst Heinrich
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Am Assoc Gynecol Laparosc. 2003 Aug;10(3):311-5. doi: 10.1016/s1074-3804(05)60253-8.
To compare the effect of intraperitoneal bupivacaine and lidocaine on reducing pain after diagnostic laparoscopy.
Randomized, double-blind, placebo-controlled study (Canadian Task Force classification I).
University teaching hospital.
One hundred thirty-four women with unexplained infertility.
Diagnostic laparoscopy with intraperitoneal administration of bupivacaine or lidocaine.
Patients were randomized into one of four groups. In group A, at the end of laparoscopy 0.125% bupivacaine 30 ml was instilled into the pelvic cavity and the same dose was instilled over the diaphragmatic vault. Groups B and C received the same volume of 5% lidocaine and normal saline, respectively. Group D received no intraperitoneal agent. The verbal pain scale questionnaire was used to assess postoperative pain. Pain scores 2 and 24 hours postoperatively were significantly lower for group A than for groups B and C (p = 0.0001). Scores in group B were also significantly lower than those in groups C and D (p = 0.0001). Women in group A required less additional analgesia than those in the other groups.
Compared with lidocaine and placebo, intraperitoneal bupivacaine significantly decreased postoperative pain, and this effect was long lasting.
比较腹腔内注射布比卡因和利多卡因对减少诊断性腹腔镜检查后疼痛的效果。
随机、双盲、安慰剂对照研究（加拿大工作组分类I）。
大学教学医院。
134名不明原因不孕症女性。
诊断性腹腔镜检查并腹腔内注射布比卡因或利多卡因。
患者被随机分为四组。A组在腹腔镜检查结束时，向盆腔内注入30毫升0.125%布比卡因，并在膈穹窿上方注入相同剂量。B组和C组分别接受相同体积的5%利多卡因和生理盐水。D组未接受腹腔内用药。采用言语疼痛量表问卷评估术后疼痛。A组术后2小时和24小时的疼痛评分显著低于B组和C组（p = 0.0001）。B组的评分也显著低于C组和D组（p = 0.0001）。A组女性所需的额外镇痛药物比其他组少。
与利多卡因和安慰剂相比，腹腔内注射布比卡因可显著减轻术后疼痛，且这种效果持久。
