Pellino Janice L, Sontheimer Erik J
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.
Cell. 2003 Oct 17;115(2):132-3. doi: 10.1016/s0092-8674(03)00806-7.
During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi.
在RNA干扰（RNAi）过程中，Dicer产生小干扰RNA（siRNA），然后这些小干扰RNA引导RISC复合物切割靶mRNA。现在，刘等人鉴定出R2D2，一种与Dicer相关的蛋白质，它对于小干扰RNA整合到RISC中很重要，从而将RNA干扰的起始阶段和执行阶段联系起来。
