Kennedy Peter G E, Grinfeld Esther, Esiri Margaret M
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Govan Road, G51 4TF Glasgow, UK.
J Neurol Sci. 2003 Nov 15;215(1-2):27-9. doi: 10.1016/s0022-510x(03)00167-9.
It has been suggested that Varicella-Zoster virus (VZV) may play a role in the pathogenesis of giant cell arteritis (GCA). We therefore used both in situ hybridisation and in situ Polymerase Chain Reaction amplification techniques in an attempt to identify VZV DNA in 15 temporal arteries from histologically proven GCA. We did not detect evidence of VZV DNA in the arteries of any of these subjects, nor in temporal arteries obtained from seven normal control subjects. VZV was detected, however, in neurons in a human trigeminal ganglion. While sampling variation and sensitivity issues are likely to play a role in the discrepancies observed in different studies of VZV in GCA, this study does not provide further support for the notion that VZV is playing a significant part in causing GCA.
有人提出水痘带状疱疹病毒（VZV）可能在巨细胞动脉炎（GCA）的发病机制中起作用。因此，我们使用原位杂交和原位聚合酶链反应扩增技术，试图在15例经组织学证实为GCA的颞动脉中鉴定VZV DNA。我们在这些受试者的任何动脉中均未检测到VZV DNA的证据，在7例正常对照受试者的颞动脉中也未检测到。然而，在人类三叉神经节的神经元中检测到了VZV。虽然抽样差异和敏感性问题可能在不同的GCA中VZV研究中观察到的差异中起作用，但本研究并未为VZV在导致GCA中起重要作用这一观点提供进一步支持。
