杏仁核点燃后大鼠海马中氯离子稳态调节基因表达的变化
Changes in chloride homeostasis-regulating gene expressions in the rat hippocampus following amygdala kindling.
作者信息
Okabe Akihito, Yokokura Masamichi, Toyoda Hiroki, Shimizu-Okabe Chigusa, Ohno Koji, Sato Kohji, Fukuda Atsuo
机构信息
Department of Physiology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka 431-3192, Japan.
出版信息
Brain Res. 2003 Nov 14;990(1-2):221-6. doi: 10.1016/s0006-8993(03)03528-5.
In a rat kindling model, we examined expression patterns of NKCC1, KCC1, KCC2, and CLC-2. In the dentate granule cell layer, there was an activity-dependent increase in NKCC1 mRNA but significant decreases in KCC1 and CLC-2 mRNAs. In addition, CLC-2 mRNA expression was markedly decreased in CA1 pyramidal layer. These results suggest that an increase in [Cl-]i and a resultant reduction in GABAergic inhibition may occur in hippocampus of epileptic rats.
在大鼠点燃模型中，我们检测了NKCC1、KCC1、KCC2和CLC-2的表达模式。在齿状颗粒细胞层，NKCC1 mRNA呈活性依赖性增加，但KCC1和CLC-2 mRNA显著减少。此外，CA1锥体层中CLC-2 mRNA表达明显降低。这些结果表明，癫痫大鼠海马中可能会出现细胞内氯离子浓度升高以及由此导致的GABA能抑制作用减弱。
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