大鼠脑中KCC1、KCC2和NKCC1 mRNA表达的发育变化。
Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain.
作者信息
Wang Cong, Shimizu-Okabe Chigusa, Watanabe Kazuo, Okabe Akihito, Matsuzaki Hideo, Ogawa Tsuguhiro, Mori Norio, Fukuda Atsuo, Sato Kohji
机构信息
Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.
出版信息
Brain Res Dev Brain Res. 2002 Nov 15;139(1):59-66. doi: 10.1016/s0165-3806(02)00536-9.
We investigated the expressions of KCC1, KCC2 and NKCC1 mRNAs in the developing rat brain. The neuroepithelium showed abundant KCC1 and NKCC1 mRNA expressions, while KCC2 mRNA was not detected there. In contrast, KCC2 mRNA was preferentially expressed in postmitotic mature neurons. These results suggest that the appearance of KCC2 expression mainly depends on the maturation of individual neurons.
我们研究了发育中大鼠大脑中KCC1、KCC2和NKCC1 mRNA的表达情况。神经上皮显示出丰富的KCC1和NKCC1 mRNA表达，而在那里未检测到KCC2 mRNA。相反，KCC2 mRNA在有丝分裂后的成熟神经元中优先表达。这些结果表明，KCC2表达的出现主要取决于单个神经元的成熟。
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