Jobard G, Crivello F, Tzourio-Mazoyer N
Groupe d'Imagerie Neurofonctionnelle, CNRS, UMR 6095, CEA LRC36V, Université de Caen, Université de Paris 5, 14074, Caen Cedex, France.
Neuroimage. 2003 Oct;20(2):693-712. doi: 10.1016/S1053-8119(03)00343-4.
Numerous studies concerned with cerebral structures underlying word reading have been published during the last decade. A few controversies, however, together with methodological or theoretical discrepancies between laboratories, still contribute to blurring the overall view of advances effected in neuroimaging. Carried out within the dual route of reading framework, the aim of this metanalysis was to provide an objective picture of these advances. To achieve this, we used an automated analysis method based on the inventory of activation peaks issued from word or pseudoword reading contrasts of 35 published neuroimaging studies. A first result of this metanalysis was that no cluster of activations has been found more recruited by word than pseudoword reading, implying that the first steps of word access may be common to word and word-like stimuli and would take place within a left occipitotemporal region (previously referred to as the Visual Word Form Area-VWFA) situated in the ventral route, at the junction between inferior temporal and fusiform gyri. The results also indicated the existence of brain regions predominantly involved in one of the two routes to access word. The graphophonological conversion seems indeed to rely on left lateralized brain structures such as superior temporal areas, supramarginal gyrus, and the opercular part of the inferior frontal gyrus, these last two regions reflecting a greater load in working memory during such an access. The lexicosemantic route is thought to arise from the coactivation of the VWFA and semantic areas. These semantic areas would encompass a basal inferior temporal area, the posterior part of the middle temporal gyrus, and the triangular part of inferior frontal gyrus. These results confirm the suitability of the dual route framework to account for activations observed in nonpathological subjects while they read.
在过去十年中，已经发表了许多关于单词阅读背后大脑结构的研究。然而，一些争议以及实验室之间在方法或理论上的差异，仍然使得神经影像学进展的整体观点变得模糊。本荟萃分析在阅读的双重路径框架内进行，旨在提供这些进展的客观情况。为了实现这一目标，我们使用了一种基于对35项已发表的神经影像学研究中单词或假词阅读对比产生的激活峰值清单的自动分析方法。该荟萃分析的第一个结果是，未发现单词阅读比假词阅读更多募集的激活簇，这意味着单词通达的最初步骤可能对于单词和类单词刺激是共同的，并且将发生在位于腹侧路径、颞下回和梭状回交界处的左侧枕颞区（先前称为视觉词形区-VWFA）内。结果还表明存在主要参与两种单词通达路径之一的脑区。字形-语音转换似乎确实依赖于左侧化的脑结构，如颞上区、缘上回和额下回的岛盖部，后两个区域在这种通达过程中反映出工作记忆中的更大负荷。词汇-语义路径被认为源于VWFA和语义区的共同激活。这些语义区将包括颞下基底区、颞中回后部和额下回三角部。这些结果证实了双重路径框架适用于解释非病理受试者阅读时观察到的激活情况。
