Schall Ulrich, Johnston Patrick, Todd Juanita, Ward Philip B, Michie Patricia T
Centre for Mental Health Studies, University of Newcastle, Australia.
Neuroimage. 2003 Oct;20(2):729-36. doi: 10.1016/S1053-8119(03)00398-7.
This study was designed to identify the neural networks underlying automatic auditory deviance detection in 10 healthy subjects using functional magnetic resonance imaging. We measured blood oxygenation level-dependent contrasts derived from the comparison of blocks of stimuli presented as a series of standard tones (50 ms duration) alone versus blocks that contained rare duration-deviant tones (100 ms) that were interspersed among a series of frequent standard tones while subjects were watching a silent movie. Possible effects of scanner noise were assessed by a "no tone" condition. In line with previous positron emission tomography and EEG source modeling studies, we found temporal lobe and prefrontal cortical activation that was associated with auditory duration mismatch processing. Data were also analyzed employing an event-related hemodynamic response model, which confirmed activation in response to duration-deviant tones bilaterally in the superior temporal gyrus and prefrontally in the right inferior and middle frontal gyri. In line with previous electrophysiological reports, mismatch activation of these brain regions was significantly correlated with age. These findings suggest a close relationship of the event-related hemodynamic response pattern with the corresponding electrophysiological activity underlying the event-related "mismatch negativity" potential, a putative measure of auditory sensory memory.
本研究旨在利用功能磁共振成像确定10名健康受试者自动听觉偏差检测背后的神经网络。我们测量了血氧水平依赖对比，该对比来自于在受试者观看无声电影时，将单独呈现为一系列标准音调（持续时间50毫秒）的刺激块与包含罕见持续时间偏差音调（100毫秒）的刺激块进行比较，这些偏差音调穿插在一系列频繁出现的标准音调中。通过“无音调”条件评估了扫描仪噪声的可能影响。与先前的正电子发射断层扫描和脑电图源模型研究一致，我们发现颞叶和前额叶皮质激活与听觉持续时间失配处理有关。数据还采用事件相关血流动力学反应模型进行分析，该模型证实了双侧颞上回以及右侧额下回和额中回前额部对持续时间偏差音调的激活。与先前的电生理报告一致，这些脑区的失配激活与年龄显著相关。这些发现表明，事件相关血流动力学反应模式与事件相关“失配负波”电位背后相应的电生理活动密切相关，“失配负波”是听觉感觉记忆的一种假定测量指标。
