Tsukiura Takashi, Namiki Masayuki, Fujii Toshikatsu, Iijima Toshio
Brain Architecture Analysis Group, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8568, Japan.
Neuroimage. 2003 Oct;20(2):784-94. doi: 10.1016/S1053-8119(03)00378-1.
Previous data have indicated that the left anterior temporal lobe contributes to the retrieval of familiar people's names, and that the extended network including the bilateral anterior temporal lobe plays an important role in the retrieval of newly learned people's names. However, there has been no direct evidence for time-dependent change in brain activation in face-name associations. In addition, previous studies have demonstrated that emotional information such as emotional faces may contribute to the organization of long-lasting episodic memory. In the present study, we investigated the activations related to the recognition of people's names in the context of emotional and neutral face-name associative learning. Before fMRI scanning, subjects learned face-name associations that included emotionally positive and neutral facial expressions. In immediate (5 min later) and delayed (2 weeks later) recognition with fMRI scanning, subjects were presented with studied faces with two names, and were asked to choose the correct associative name learned previously. Recognition-related activations were identified in the anterior part of bilateral temporal lobe for immediate recognition and only in the left temporal lobe for delayed recognition. Further analysis confirmed the time-dependent change in activation of the right anterior temporal lobe. Activation related to the processing of faces with positive expressions were observed in the left periamygdaloid area and temporal pole, although emotional information did not have an influence on task performance in this study. These findings suggest that the neural network involving the bilateral temporal lobe contributes to the retrieval of newly learned people's names, and that the left temporal lobe has a crucial and stable role in retrieval of people's names from faces, whereas the role of the right temporal lobe in retrieval of people's names may decrease with the time course.
先前的数据表明，左前颞叶有助于熟悉人名的提取，并且包括双侧前颞叶在内的扩展网络在新学人名的提取中起重要作用。然而，对于面孔-名字关联中大脑激活的时间依赖性变化，尚无直接证据。此外，先前的研究表明，诸如情感面孔等情感信息可能有助于持久情景记忆的组织。在本研究中，我们调查了在情感和中性面孔-名字联想学习背景下与名字识别相关的激活情况。在功能磁共振成像（fMRI）扫描前，受试者学习了包括情感积极和中性面部表情的面孔-名字关联。在fMRI扫描的即时（5分钟后）和延迟（2周后）识别中，向受试者呈现带有两个名字的已学面孔，并要求他们选择先前学习的正确关联名字。在即时识别中，双侧颞叶前部发现了与识别相关的激活，而在延迟识别中仅在左颞叶发现。进一步分析证实了右前颞叶激活的时间依赖性变化。尽管在本研究中情感信息对任务表现没有影响，但在左侧杏仁核周围区域和颞极观察到了与积极表情面孔处理相关的激活。这些发现表明，涉及双侧颞叶的神经网络有助于新学人名的提取，并且左颞叶在从面孔中提取人名方面具有关键且稳定的作用，而右颞叶在人名提取中的作用可能会随着时间推移而降低。
