Billington W David
J Reprod Immunol. 2003 Oct;60(1):1-11. doi: 10.1016/s0165-0378(03)00083-4.
This article is a tribute to the late Sir Peter Brian Medawar for his pivotal contribution in 1953 to the establishment of the field of Reproductive Immunology, with a brief and selective assessment of the progress made during the ensuing 50 years towards elucidation of the mechanisms responsible for the paradoxical survival of the conceptus as an intra-uterine allograft within the immunologically competent genetically alien female host. Medawar's succinct and stimulating theories have been central throughout the whole of this time and his basic conclusion, that the single most important factor ensuring the success of gestation is the anatomical separation of the fetus from its mother, remains substantially valid to this day. The extent to which other factors are of significance, particularly those relating to the relative roles of maternal adaptive and innate immune responses to the developing feto-placental unit, has yet to be fully defined.
本文是对已故的彼得·布莱恩·梅达瓦尔爵士的致敬，他在1953年对生殖免疫学领域的建立做出了关键贡献。本文还简要且有选择性地评估了在随后的50年里，在阐明胚胎作为子宫内同种异体移植物，在具有免疫活性的基因异源雌性宿主中异常存活的机制方面所取得的进展。梅达瓦尔简洁而富有启发性的理论在这段时间里一直处于核心地位，他的基本结论，即确保妊娠成功的最重要因素是胎儿与母亲的解剖学分离，至今在很大程度上仍然有效。其他因素的重要程度，特别是那些与母体适应性和先天性免疫反应对发育中的胎儿 - 胎盘单位的相对作用相关的因素，尚未完全明确。
