Wiley R W, Kotulak J C, Behar I
Sensory Research Division, U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL 36362-5292.
Aviat Space Environ Med. 1992 Dec;63(12):1054-9.
The effects of pyridostigmine bromide (PB) on selected visual functions were measured on four healthy aviator candidates. Following a pretreatment day during which baseline measurements were completed, subjects were administered currently recommended doses (30 mg, t.i.d.) of PB for 3 d during which their visual functions were assessed using a repeated measures design. Spatial resolution ability was evaluated with high and low contrast visual acuity charts and contrast sensitivity charts at three luminance levels. Dark adaptation was evaluated by measuring visual thresholds for 40 min after a standardized retinal photopigment bleach. Also, refractive error and several oculomotor functions (lateral phoria, fusional vergence, accommodative amplitude, and pupil size) were measured. On days that the subjects ingested PB, only refractive error and pupil diameter were significantly different, and these only minimally. We conclude that the use of PB at doctrinal doses will not significantly compromise an aviator's visual ability.
对四名健康的飞行员候选人测量了溴吡斯的明（PB）对选定视觉功能的影响。在完成基线测量的预处理日之后，受试者接受目前推荐剂量（30毫克，每日三次）的PB，持续3天，在此期间使用重复测量设计评估他们的视觉功能。在三个亮度水平下，使用高对比度和低对比度视力表以及对比敏感度表评估空间分辨能力。通过在标准化视网膜光色素漂白后测量40分钟的视觉阈值来评估暗适应。此外，还测量了屈光不正和几种眼动功能（水平隐斜、融合性聚散、调节幅度和瞳孔大小）。在受试者摄入PB的日子里，只有屈光不正和瞳孔直径有显著差异，而且差异很小。我们得出结论，按规定剂量使用PB不会显著损害飞行员的视觉能力。
