雌激素代谢产物与老年女性患乳腺癌的风险
Estrogen metabolites and the risk of breast cancer in older women.
作者信息
Cauley Jane A, Zmuda Joseph M, Danielson Michelle E, Ljung Britt-Marie, Bauer Douglas C, Cummings Steven R, Kuller Lewis H
机构信息
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Epidemiology. 2003 Nov;14(6):740-4. doi: 10.1097/01.ede.0000091607.77374.74.
BACKGROUND
Women who metabolize a large proportion of their estrogen via the 16alpha hydroxylation pathway could be at a higher risk of breast cancer. The objective of this study was to test the hypothesis that serum concentrations of 2-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1), as well as their ratio, predict the risk of breast cancer in older women.
METHODS
We performed a case-cohort study of 272 women with confirmed incident breast cancer and 291 controls chosen randomly from the cohort. Estrogen metabolites were measured in serum collected at the baseline examination and stored at -120 degrees C. Incident breast cancers were confirmed by medical records and pathology reports during an average follow-up of 8.7 years.
RESULTS
Mean concentrations of 2-OHE1 and 16alpha-OHE1, adjusted for age and body mass index, were 3% to 4% higher in cases compared with controls: 2-OHE1 was 176 pg/mL and 169 pg/mL and 16alpha-OHE1 was 233 pg/mL and 226 pg/mL in cases and controls, respectively. There was, however, no difference in the ratio of 2-OHE1 to 16alpha-OHE1. The risk of breast cancer in women with the highest quartile of this ratio compared with those in the lowest quartile was 1.17 (95% confidence interval = 0.73-1.87).
CONCLUSION
The study results do not support the hypothesis that the ratio of 2-OHE1 to 16alpha-OHE1 predicts breast cancer risk.
背景
通过16α-羟基化途径代谢大部分雌激素的女性可能患乳腺癌的风险更高。本研究的目的是检验以下假设：血清2-羟雌酮（2-OHE1）和16α-羟雌酮（16α-OHE1）的浓度及其比值可预测老年女性患乳腺癌的风险。
方法
我们对272例确诊为新发乳腺癌的女性和从队列中随机选取的291例对照进行了病例队列研究。在基线检查时采集血清并储存于-120℃，检测雌激素代谢产物。在平均8.7年的随访期间，通过病历和病理报告确诊新发乳腺癌。
结果
校正年龄和体重指数后，病例组中2-OHE1和16α-OHE1的平均浓度比对照组高3%至4%：病例组中2-OHE1分别为176 pg/mL和169 pg/mL，16α-OHE1分别为233 pg/mL和226 pg/mL。然而，2-OHE1与16α-OHE1的比值没有差异。该比值处于最高四分位数的女性患乳腺癌的风险与最低四分位数的女性相比为1.17（95%置信区间=0.73-1.87）。
结论
研究结果不支持2-OHE1与16α-OHE1的比值可预测乳腺癌风险这一假设。
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