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[硝苯地平和醋丁洛尔急性中毒:两例报告]

[Acute poisoning with nifedipine and acebutol: two cases].

作者信息

Groszek Barbara, Szpak Dorota, Kłys Małogorzata, Scisłowski Mariusz

机构信息

Klinika Toksykologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, 31-826 Kraków, Os. Złotej Jesieni 1.

出版信息

Przegl Lek. 2003;60(4):262-4.

PMID:14569898
Abstract

In this paper the case of intoxication in two women (19-year-old and 23-year-old), who in suicide attempts ingested at the same time different doses of nifedipine and acebutol. In 23-year-old woman 4 hours post ingestion cardiorespiratory arrest was stated. Resuscitation procedures were ineffective, she died. Acebutol concentration in postmortem blood was 24.1 mg/l and nifedipine-1.8 mg/l. The second one (19-year-old) was treated successfully, only mild cardiac disturbances were observed. Acebutol concentration in blood was 1.8 mg/l, nifedipine was not stated.

摘要

本文报道了两名女性(分别为19岁和23岁)中毒的病例,她们在自杀未遂时同时摄入了不同剂量的硝苯地平和醋丁洛尔。在23岁女性摄入药物4小时后,出现了心肺骤停。复苏程序无效,她死亡。死后血液中醋丁洛尔浓度为24.1毫克/升,硝苯地平浓度为1.8毫克/升。另一名(19岁)患者治疗成功,仅观察到轻度心脏功能紊乱。血液中醋丁洛尔浓度为1.8毫克/升,未提及硝苯地平的浓度。

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引用本文的文献

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Pharmacological and mechanical management of calcium channel blocker toxicity.钙通道阻滞剂中毒的药物及机械处理
BMJ Case Rep. 2018 Aug 27;2018:bcr-2018-225324. doi: 10.1136/bcr-2018-225324.
2
Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults.成人钙通道阻滞剂中毒管理的专家共识建议
Crit Care Med. 2017 Mar;45(3):e306-e315. doi: 10.1097/CCM.0000000000002087.
3
Treatment for calcium channel blocker poisoning: a systematic review.钙通道阻滞剂中毒的治疗:系统评价。
Clin Toxicol (Phila). 2014 Nov;52(9):926-44. doi: 10.3109/15563650.2014.965827. Epub 2014 Oct 6.