Love J N
Consultant to the National Capital (Washington, DC) and Maryland (Baltimore) Poison Centers, Department of Emergency Medicine, Georgetown University Hospital, Washington, DC, USA.
J Emerg Med. 2000 Apr;18(3):341-4. doi: 10.1016/s0736-4679(99)00225-5.
Two fatal cases of Acebutolol intoxication are presented that demonstrate its clinical characteristics and potential lethality. A review of the literature suggests that acebutolol is one of the most toxic beta blockers when taken as an overdose. In addition to demonstrating characteristics of membrane-stabilizing activity, both fatal cases demonstrate significant QTc prolongation and ventricular tachycardia. The latter findings suggest an impact on ventricular repolarization not seen with Propranolol intoxication. Clarification of these findings has important implications regarding identification and treatment of this potentially fatal intoxication.
本文报告了两例醋丁洛尔中毒致死病例，展现了其临床特征及潜在致死性。文献综述表明，醋丁洛尔是过量服用时毒性最强的β受体阻滞剂之一。除了表现出膜稳定活性特征外，两例致死病例均出现显著的QTc间期延长和室性心动过速。后一项发现表明，醋丁洛尔对心室复极化的影响与普萘洛尔中毒不同。明确这些发现对于识别和治疗这种潜在致命性中毒具有重要意义。
