Notch在肿瘤发生中的作用：癌基因还是肿瘤抑制基因？

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

作者信息

Radtke Freddy, Raj Kenneth

机构信息

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.

出版信息

Nat Rev Cancer. 2003 Oct;3(10):756-67. doi: 10.1038/nrc1186.

DOI:10.1038/nrc1186

PMID:14570040

Abstract

Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.

摘要

Notch信号通路通过维持某些组织的自我更新潜能并诱导其他组织分化来参与多细胞生物体的发育。Notch在癌症中的作用最早在人类T细胞白血病中得到凸显，这促使人们认为异常的Notch信号通路会促进肿瘤发生。然而，越来越多的证据表明，Notch信号通路并非完全具有致癌性。相反，它可以起到肿瘤抑制作用。