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氢化松香成膜性能的评估。

Evaluation of the film-forming property of hydrogenated rosin.

作者信息

Satturwar P M, Fulzele S V, Joshi S B, Dorle A K

机构信息

Department of Pharmaceutical Sciences, Nagpur University, Nagpur, India.

出版信息

Drug Dev Ind Pharm. 2003 Sep;29(8):877-84. doi: 10.1081/ddc-120024183.

Abstract

The film-forming and coating properties of a new biomaterial, hydrogenated rosin (HR), is investigated in the present communication. Films produced by casting method are studied for mechanical, (tensile strength, elongation, and Young's modulus), water vapor transmission, and moisture absorption characteristics. Type of plasticizer and its concentration were observed to play an important role in modifying the film characteristics. Dibutyl sebacate (DBS), a hydrophobic plasticizer, was found to be suitable for development of flexible and smooth films. Film formulations plasticized with DBS were investigated for coating the drug layered nonpareil seeds where plasticization facilitated development of smooth and uniformly coated pellets. The increase in coat buildup, however, did not sustain the drug release significantly. The studies conclude that HR films promise utility as moisture-protective hydrophobic, film-coating materials.

摘要

本文研究了一种新型生物材料氢化松香(HR)的成膜和包衣性能。通过流延法制备的薄膜被研究了其机械性能(拉伸强度、伸长率和杨氏模量)、水蒸气透过率和吸湿特性。观察到增塑剂的类型及其浓度在改变薄膜特性方面起着重要作用。癸二酸二丁酯(DBS),一种疏水性增塑剂,被发现适用于制备柔性光滑的薄膜。研究了用DBS增塑的薄膜配方用于包衣药物层状非pareil种子,其中增塑促进了光滑且均匀包衣微丸的形成。然而,包衣厚度的增加并没有显著维持药物释放。研究得出结论,HR薄膜有望作为防潮疏水性薄膜包衣材料发挥作用。

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