Cain Christopher K, Blouin Ashley M, Barad Mark
Interdepartmental Program in Neuroscience, University of California, Los Angeles, CA 90095-1761, USA.
J Exp Psychol Anim Behav Process. 2003 Oct;29(4):323-33. doi: 10.1037/0097-7403.29.4.323.
Rodent fear conditioning models both excitatory learning and the pathogenesis of human anxiety, whereas extinction of conditional fear is a paradigm of inhibitory learning and the explicit model for behavior therapy. Many studies support a general learning rule for acquisition: Temporally spaced training is more effective than massed training. The authors asked whether this rule applies to extinction of conditional fear in mice. The authors find that both short- and long-term fear extinction are greater with temporally massed presentations of the conditional stimulus (CS). The data also indicate that once CS presentations are sufficiently massed to initiate, or "induce," extinction learning, further CS presentations are more effective when spaced.
啮齿动物恐惧条件反射既模拟了兴奋性学习，也模拟了人类焦虑症的发病机制，而条件性恐惧的消退是抑制性学习的范例，也是行为疗法的明确模型。许多研究支持一种普遍的学习规则：间隔训练比集中训练更有效。作者们探讨了这一规则是否适用于小鼠条件性恐惧的消退。作者们发现，条件刺激（CS）在时间上集中呈现时，短期和长期的恐惧消退效果都更好。数据还表明，一旦CS呈现足够集中以启动或“诱导”消退学习，CS进一步呈现时，间隔呈现则更有效。
