Ragozzino Michael E, Kim Jenna, Hassert Derrick, Minniti Nancy, Kiang Charlene
Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA.
Behav Neurosci. 2003 Oct;117(5):1054-65. doi: 10.1037/0735-7044.117.5.1054.
The experiments examined the effects of prelimbic-infralimbic inactivation in rats on the acquisition and reversal learning of different discrimination tasks: 2- or 4-choice odor discrimination in Experiments 1 and 2, the shift from 2-choice odor discrimination to 2-choice place discrimination in Experiment 3, and the shift from 2-choice place to 2-choice odor discrimination in Experiment 4. Infusions of 2% bupivacaine did not impair performance in the odor discrimination tests. Prelimbic-infralimbic inactivation did not impair acquisition but did impair the shift from an odor to a place discrimination and vice versa. Analysis of the errors revealed that the deficit was due to perseveration of the previously learned strategy. The selective deficits observed in the odor-place tests suggest that the prelimbic-infralimbic areas enable behavioral flexibility when conditions demand inhibiting the use of one type of attribute information and learning a new type of attribute information.
这些实验研究了大鼠前边缘-下边缘区失活对不同辨别任务的习得和逆向学习的影响：实验1和实验2中的二选一或四选一气味辨别任务、实验3中从二选一气味辨别任务到二选一位置辨别任务的转换，以及实验4中从二选一位置辨别任务到二选一气味辨别任务的转换。注入2%布比卡因不会损害气味辨别测试中的表现。前边缘-下边缘区失活不会损害习得，但会损害从气味辨别到位置辨别的转换，反之亦然。对错误的分析表明，缺陷是由于坚持使用先前学到的策略所致。在气味-位置测试中观察到的选择性缺陷表明，当条件要求抑制使用一种类型的属性信息并学习一种新的属性信息时，前边缘-下边缘区能使行为具有灵活性。
