Johi R R, Mills R, Halsall P J, Hopkins P M
Department of Anaesthesia, William Harvey Hospital, Kennington Road, Ashford, Kent TN23 3AQ, UK.
Br J Anaesth. 2003 Nov;91(5):744-7. doi: 10.1093/bja/aeg262.
Central core disease and malignant hyperthermia (MH) are both associated with mutations in the RYR1 gene. We report the anaesthetic management of one such patient presenting for coronary artery bypass grafting. Her medication included aspirin 75 mg, atorvastatin 20 mg, isosorbide mononitrate 60 mg, atenolol 25 mg and glyceryl trinitrite sublingual spray as required. The use of aprotinin, statins and moderate hypothermia in patients with central core disease and known susceptibility to MH has not been documented.
中央轴空病与恶性高热（MH）均与兰尼碱受体1（RYR1）基因突变有关。我们报告了1例此类拟行冠状动脉旁路移植术患者的麻醉处理情况。她的用药包括75毫克阿司匹林、20毫克阿托伐他汀、60毫克单硝酸异山梨酯、25毫克阿替洛尔以及必要时使用的硝酸甘油舌下喷雾剂。对于中央轴空病且已知对MH易感的患者，使用抑肽酶、他汀类药物及适度低温的情况尚无文献记载。
