帕金森病中与年龄和病程相关的肌肉交感神经活动变化。
Age and duration related changes in muscle sympathetic nerve activity in Parkinson's disease.
作者信息
Shindo K, Watanabe H, Tanaka H, Ohashi K, Nagasaka T, Tsunoda S, Shiozawa Z
机构信息
Department of Neurology, Yamanashi Medical University, Yamanashi, Japan.
出版信息
J Neurol Neurosurg Psychiatry. 2003 Oct;74(10):1407-11. doi: 10.1136/jnnp.74.10.1407.
OBJECTIVE
To clarify the characteristics of sympathetic vasomotor function in Parkinson's disease by sympathetic neurographic analysis.
METHODS
Muscle sympathetic nerve activity (MSNA) was recorded using a microneurographic technique at rest and during head up tilt in 18 patients with idiopathic Parkinson's disease and 21 healthy controls.
RESULTS
Heart rate and blood pressure at rest did not differ between index and control subjects. The increase in these variables and MSNA in response to tilting was slightly blunted in the Parkinson's group. Resting MSNA showed a negative correlation with age in patients with Parkinson's disease (p<0.05) and a positive correlation with age in controls (p<0.01). There was a negative correlation between duration of disease or disability levels and MSNA (p<0.01).
CONCLUSIONS
Sympathetic vasomotor function may be related to age and disease duration in Parkinson's disease.
目的
通过交感神经电图分析阐明帕金森病交感血管运动功能的特征。
方法
采用微神经电图技术，对18例特发性帕金森病患者和21名健康对照者在静息状态及头高位倾斜时的肌肉交感神经活动（MSNA）进行记录。
结果
研究对象与对照者的静息心率和血压无差异。帕金森病组在倾斜时这些变量及MSNA的增加略有减弱。帕金森病患者静息MSNA与年龄呈负相关（p<0.05），而对照组中静息MSNA与年龄呈正相关（p<0.01）。疾病持续时间或残疾程度与MSNA之间存在负相关（p<0.01）。
结论
帕金森病中交感血管运动功能可能与年龄和疾病持续时间有关。
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