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脊髓硬脊膜动静脉瘘:80例患者的临床特征

Spinal dural arteriovenous fistulas: clinical features in 80 patients.

作者信息

Jellema K, Canta L R, Tijssen C C, van Rooij W J, Koudstaal P J, van Gijn J

机构信息

Department of Neurology, St. Elisabeth Hospital, Tilburg, The Netherlands.

出版信息

J Neurol Neurosurg Psychiatry. 2003 Oct;74(10):1438-40. doi: 10.1136/jnnp.74.10.1438.

Abstract

The aim of this study was to describe the clinical spectrum of spinal dural arteriovenous fistulas (SDAF) in a large group of patients. We studied the records of 80 patients who were diagnosed with an SDAF in six hospitals over a 15 year period (1985-2001). We extracted data on demographic variables, initial symptoms, symptoms at the time of diagnosis, level of SDAF, and medical history. Most patients were middle aged men, and most SDAF were located in the midthoracic region. The median time to diagnosis of 80 patients with an SDAF was 15 months (range 7 days-197 months). The most common initial symptoms were gait disturbances (34%), numbness (24%), and paresthesias (21%). At the time of diagnosis, most common symptoms were micturition problems (80%), leg weakness (78%), and numbness in the legs or buttocks (69%). The combination of all three symptoms was present in 58% of patients. Any symptoms or signs related to sacral segments had developed in 67 patients (84%). Fifteen patients (19%) had become wheelchair bound. SDAF is difficult to diagnose, and the delay between first symptoms and treatment is often long. In middle aged men who present with disturbances of gait with ascending motor and sensory deficits, and who subsequently report impaired voiding or other sphincter disturbance, SDAF is one of the first diagnoses that should spring to mind.

摘要

本研究的目的是描述一大组脊髓硬脊膜动静脉瘘(SDAF)患者的临床特征。我们研究了在15年期间(1985 - 2001年)于6家医院被诊断为SDAF的80例患者的病历。我们提取了关于人口统计学变量、初始症状、诊断时的症状、SDAF的位置以及病史的数据。大多数患者为中年男性,且大多数SDAF位于胸段中部。80例SDAF患者诊断的中位时间为15个月(范围7天 - 197个月)。最常见的初始症状为步态障碍(34%)、麻木(24%)和感觉异常(21%)。在诊断时,最常见的症状为排尿问题(80%)、腿部无力(78%)以及腿部或臀部麻木(69%)。58%的患者出现了这三种症状的组合。67例患者(84%)出现了与骶段相关的任何症状或体征。15例患者(19%)已依赖轮椅。SDAF难以诊断,且从首次出现症状到治疗的延迟通常很长。对于出现步态障碍并伴有上行性运动和感觉功能缺损,随后报告排尿障碍或其他括约肌功能障碍的中年男性,SDAF是首先应想到的诊断之一。

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