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Diaplacental carcinogenesis: tumor localization and tumor incidence in NMRI mice after diaplacental initiation with DMBA and urethane and postnatal promotion and the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.

作者信息

Goerttler K, Löhrke H

出版信息

Virchows Arch A Pathol Anat Histol. 1977 Nov 17;376(2):117-32. doi: 10.1007/BF00432583.

DOI:10.1007/BF00432583
PMID:145710
Abstract
摘要

相似文献

1
Diaplacental carcinogenesis: tumor localization and tumor incidence in NMRI mice after diaplacental initiation with DMBA and urethane and postnatal promotion and the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.经胎盘致癌作用：在改良的两阶段贝伦布卢姆/莫特拉姆实验中，用二甲基苯并蒽（DMBA）和氨基甲酸乙酯进行经胎盘启动，并用佛波酯TPA进行产后促癌后，NMRI小鼠的肿瘤定位和肿瘤发生率。
Virchows Arch A Pathol Anat Histol. 1977 Nov 17;376(2):117-32. doi: 10.1007/BF00432583.
2
Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.经胎盘致癌作用：在改良的两阶段贝伦布卢姆/莫特拉姆实验中，在胎儿期用致癌物二甲基苯并蒽（DMBA）和氨基甲酸乙酯引发，产后用佛波酯TPA促进。
Virchows Arch A Pathol Anat Histol. 1976 Nov 22;372(1):29-38. doi: 10.1007/BF00429714.
3
Improved tumour yields by means of a TPA-DMBA-TPA variation of the Berenrlum-Mottram experiment on the back skin of NMRI mice. The effect of stationary hyperplasia without inflammation.
Exp Pathol (Jena). 1976;12(6):336-41. doi: 10.1016/s0014-4908(76)80009-9.
4
Systemic two-stage carcinogenesis in the epithelium of the forestomach of mice using 7,12-dimethylbenz(a)anthracene as initiator and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate as promoter.以7,12-二甲基苯并(a)蒽为引发剂、佛波酯12-O-十四酰佛波醇-13-乙酸酯为促癌剂，在小鼠前胃上皮细胞中进行的系统性两阶段致癌作用。
Cancer Res. 1979 Apr;39(4):1293-7.
5
Diaplacental initiation of NMRI mice with 7,12-dimethylbenz[a]anthracene during gestation days 6--20 and postnatal treatment of the F1-generation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate: tumor incidence in organs other than the skin.在妊娠第6至20天用7,12 - 二甲基苯并[a]蒽对NMRI小鼠进行经胎盘起始处理，并对F1代小鼠产后用佛波酯12 - O - 十四酰佛波醇 - 13 - 乙酸酯进行处理：皮肤以外器官的肿瘤发生率
Carcinogenesis. 1981;2(11):1087-94. doi: 10.1093/carcin/2.11.1087.
6
Development of a system for controlled release of benzo(a)pyrene, 7,12-dimethylbenz(a)anthracene, and phorbol ester for tumor induction in heterotopic tracheal grafts.用于在异位气管移植物中诱导肿瘤的苯并(a)芘、7,12-二甲基苯并(a)蒽和佛波酯控释系统的开发。
Cancer Res. 1978 May;38(5):1376-83.
7
Two-stage carcinogenesis in NMRI mice: intravaginal application of 7,12-dimethylbenz[a]anthracene as initiator followed by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate as promoter.NMRI小鼠的两阶段致癌作用：经阴道应用7,12-二甲基苯并[a]蒽作为引发剂，随后应用佛波酯12-O-十四烷酰佛波醇-13-乙酸酯作为促癌剂。
Carcinogenesis. 1980 Aug;1(8):707-13. doi: 10.1093/carcin/1.8.707.
8
Transmaternal modification of the Berenblum/Mottram experiment in mice.小鼠中Berenblum/Mottram实验的经母体修饰
Bull Cancer. 1978;65(3):265-70.
9
Transmaternal variation of the Berenblum experiment with NMRI-mice: tumour initiation with DMBA via mothers milk followed by promotion with the phorbol ester TPA.
Virchows Arch A Pathol Anat Histol. 1976 May 3;370(2):97-102. doi: 10.1007/BF00430806.
10
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.通过在妊娠第6至20天用7,12 - 二甲基苯并(a)蒽对怀孕小鼠进行全身启动，并在F1代出生后用佛波酯12 - 十四酰佛波醇-13 - 乙酸酯进行促进，诱导两阶段皮肤癌发生。
J Cancer Res Clin Oncol. 1980;98(3):267-75. doi: 10.1007/BF00410789.

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Long-Term Latency of Highly Mutated Cells in Normal Mouse Skin Is Reversed by Exposure to Tumor Promoters and Chronic Tissue Damage.正常小鼠皮肤中高度突变细胞的长期潜伏期可通过暴露于肿瘤启动子和慢性组织损伤而逆转。
Cancer Discov. 2025 Jun 3;15(6):1115-1128. doi: 10.1158/2159-8290.CD-24-1379.
2
Effects of low level microwave radiation on carcinogenesis in Swiss Albino mice.低水平微波辐射对瑞士白化小鼠致癌作用的影响。
Mol Cell Biochem. 2011 Feb;348(1-2):191-7. doi: 10.1007/s11010-010-0654-8. Epub 2010 Nov 18.
3
Transplacental arsenic carcinogenesis in mice.

本文引用的文献

1
[Problems of terminology and concepts in pathology of the prenatal period].[产前病理学中的术语和概念问题]
Virchows Arch Pathol Anat Physiol Klin Med. 1957;330(1):35-84. doi: 10.1007/BF00955157.
2
Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.阴道腺癌。年轻女性母亲接受己烯雌酚治疗与肿瘤出现的关联。
N Engl J Med. 1971 Apr 22;284(15):878-81. doi: 10.1056/NEJM197104222841604.
3
Teratogenesis-oncogenesis: a study of possible relationships.
小鼠经胎盘的砷致癌作用。
Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80. doi: 10.1016/j.taap.2006.12.034. Epub 2007 Jan 12.
4
Cocarcinogenesis and tumor promoters of the diterpene ester type as possible carcinogenic risk factors.二萜酯类的协同致癌作用及肿瘤促进剂作为可能的致癌风险因素。
J Cancer Res Clin Oncol. 1981;99(1-2):103-24. doi: 10.1007/BF00412447.
5
Induction of mouse hepatic ornithine decarboxylase by skin application of 12-0-tetradecanoylphorbol-13-acetate.通过皮肤涂抹12-0-十四酰佛波醇-13-乙酸酯诱导小鼠肝脏鸟氨酸脱羧酶
Experientia. 1981 Feb 15;37(2):179-80. doi: 10.1007/BF01963220.
6
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.通过在妊娠第6至20天用7,12 - 二甲基苯并(a)蒽对怀孕小鼠进行全身启动，并在F1代出生后用佛波酯12 - 十四酰佛波醇-13 - 乙酸酯进行促进，诱导两阶段皮肤癌发生。
J Cancer Res Clin Oncol. 1980;98(3):267-75. doi: 10.1007/BF00410789.
7
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.以7,12-二甲基苯并(a)蒽（DMBA）为引发剂、12-O-十四酰佛波醇-13-乙酸酯（TPA）为促进剂，在雌性斯普拉格-道利大鼠中进行的阳性两阶段致癌作用。一项初步研究的结果。
Virchows Arch A Pathol Anat Histol. 1980;385(2):181-6. doi: 10.1007/BF00427403.
8
Induction of granulocyte-macrophage colony-stimulating activity in mouse skin by inflammatory agents and tumor promoters.炎症因子和肿瘤启动子在小鼠皮肤中诱导粒细胞-巨噬细胞集落刺激活性。
EMBO J. 1983;2(11):1877-82. doi: 10.1002/j.1460-2075.1983.tb01674.x.
9
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?在一项经过改良的两阶段贝伦布卢姆/莫特拉姆实验中，用佛波酯TPA进行产后促癌，小鼠产前X射线照射能否起到引发刺激作用？
J Cancer Res Clin Oncol. 1980;97(2):109-17. doi: 10.1007/BF00409896.
10
Differential carcinogenic effects of intraperitoneal initiation with 7,12-dimethylbenz(a)anthracene or urethane and topical promotion with 12-O-tetradecanoylphorbol-13-acetate in skin and internal tissues of female SENCAR and BALB/c mice.7,12-二甲基苯并(a)蒽或氨基甲酸乙酯腹腔注射启动以及12-O-十四烷酰佛波醇-13-乙酸酯局部促癌对雌性SENCAR和BALB/c小鼠皮肤及内部组织的不同致癌作用。
Environ Health Perspect. 1986 Sep;68:61-8. doi: 10.1289/ehp.866861.
Arch Pathol. 1966 Jan;81(1):3-23.
4
[Morphology of transplacentally induced neurogenic tumors in Syrian hamsters].[叙利亚仓鼠经胎盘诱导的神经源性肿瘤的形态学]
Acta Neuropathol. 1972;21(3):194-203. doi: 10.1007/BF00688498.
5
Transplacentar induction of neurogenic malignomas by 1,2-diethyl-hydrazine, azo-, and azoxy-ethane in rats.1,2 - 二乙基肼、偶氮乙烷和氧化偶氮乙烷经胎盘诱导大鼠发生神经源性恶性肿瘤
Experientia. 1968 Jun 15;24(6):561-2. doi: 10.1007/BF02153772.
6
[Carcinogen-induced diaplacental effects in the rat. (Histological findings and the kinetics of DNA metabolism following the application of aflatoxin B1, methylazoxymethanol-acetate, and ethylnitrosourea)].[致癌物诱导的大鼠胎盘效应。（黄曲霉毒素B1、乙酸甲基偶氮甲醇和乙基亚硝基脲应用后的组织学发现及DNA代谢动力学）]
Z Krebsforsch. 1970;74(4):396-411.
7
Transplacental carcinogenesis.经胎盘致癌作用
Proc R Soc Med. 1975 Oct;68(10):655-7. doi: 10.1177/003591577506801025.
8
Prenatal exposure to stilbestrol. A prospective comparison of exposed female offspring with unexposed controls.产前暴露于己烯雌酚。暴露的雌性后代与未暴露对照组的前瞻性比较。
N Engl J Med. 1975 Feb 13;292(7):334-9. doi: 10.1056/NEJM197502132920704.
9
Protein synthesis during fetal development of mouse epidermis. I. The appearance of "histidine-rich protein".
Dev Biol. 1977 Oct 15;60(2):442-52. doi: 10.1016/0012-1606(77)90141-5.
10
Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.经胎盘致癌作用：在改良的两阶段贝伦布卢姆/莫特拉姆实验中，在胎儿期用致癌物二甲基苯并蒽（DMBA）和氨基甲酸乙酯引发，产后用佛波酯TPA促进。
Virchows Arch A Pathol Anat Histol. 1976 Nov 22;372(1):29-38. doi: 10.1007/BF00429714.