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经胎盘致癌作用：在改良的两阶段贝伦布卢姆/莫特拉姆实验中，在胎儿期用致癌物二甲基苯并蒽（DMBA）和氨基甲酸乙酯引发，产后用佛波酯TPA促进。

Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.

作者信息

Goerttler K, Loehrke H

出版信息

Virchows Arch A Pathol Anat Histol. 1976 Nov 22;372(1):29-38. doi: 10.1007/BF00429714.

DOI:10.1007/BF00429714
PMID:827081
Abstract

Diaplacental initiation with the carcinogens DMBA or urethane followed by topical treatment of mice of F-1 generation with the tumor promotor TPA led to the formation of benign and malignant tumors on the back skin and also in various internal organs. (This system constitutes a modified 2-stage experiment based on the early schemes of Berenblum and Mottram.) Application of either the carcinogens or the tumor promoter alone did not lead to the formation of tumors within one year. The highest skin papilloma yield was obtained with mice initiated with DMBA from the 16--19th day of fetal life. The highest total tumor yield was obtained after initiation from day 18--21st. The combination urethane/TPA also promoted the formation of tumors of the skin and other organs. The significance of this modified prenatal-postnatal initiation/promotion scheme in human pathology is discussed.

摘要

用致癌物二甲基苯蒽（DMBA）或氨基甲酸乙酯进行胎盘内起始作用，随后对F-1代小鼠背部皮肤局部给予肿瘤促进剂佛波酯（TPA），可导致背部皮肤以及各种内脏器官形成良性和恶性肿瘤。（该系统构成了一个基于贝伦布卢姆和莫特拉姆早期方案的改良两阶段实验。）单独应用致癌物或肿瘤促进剂在一年内均未导致肿瘤形成。在胎儿期第16 - 19天用DMBA起始的小鼠，皮肤乳头瘤发生率最高。从第18 - 21天起始后，总肿瘤发生率最高。氨基甲酸乙酯/TPA组合也促进了皮肤和其他器官肿瘤的形成。本文讨论了这种改良的产前 - 产后起始/促进方案在人类病理学中的意义。

相似文献

1
Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.经胎盘致癌作用：在改良的两阶段贝伦布卢姆/莫特拉姆实验中，在胎儿期用致癌物二甲基苯并蒽（DMBA）和氨基甲酸乙酯引发，产后用佛波酯TPA促进。
Virchows Arch A Pathol Anat Histol. 1976 Nov 22;372(1):29-38. doi: 10.1007/BF00429714.
2
Diaplacental carcinogenesis: tumor localization and tumor incidence in NMRI mice after diaplacental initiation with DMBA and urethane and postnatal promotion and the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.经胎盘致癌作用：在改良的两阶段贝伦布卢姆/莫特拉姆实验中，用二甲基苯并蒽（DMBA）和氨基甲酸乙酯进行经胎盘启动，并用佛波酯TPA进行产后促癌后，NMRI小鼠的肿瘤定位和肿瘤发生率。
Virchows Arch A Pathol Anat Histol. 1977 Nov 17;376(2):117-32. doi: 10.1007/BF00432583.
3
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.通过在妊娠第6至20天用7,12 - 二甲基苯并(a)蒽对怀孕小鼠进行全身启动，并在F1代出生后用佛波酯12 - 十四酰佛波醇-13 - 乙酸酯进行促进，诱导两阶段皮肤癌发生。
J Cancer Res Clin Oncol. 1980;98(3):267-75. doi: 10.1007/BF00410789.
4
Transmaternal modification of the Berenblum/Mottram experiment in mice.小鼠中Berenblum/Mottram实验的经母体修饰
Bull Cancer. 1978;65(3):265-70.
5
Improved tumour yields by means of a TPA-DMBA-TPA variation of the Berenrlum-Mottram experiment on the back skin of NMRI mice. The effect of stationary hyperplasia without inflammation.
Exp Pathol (Jena). 1976;12(6):336-41. doi: 10.1016/s0014-4908(76)80009-9.
6
Diaplacental initiation of NMRI mice with 7,12-dimethylbenz[a]anthracene during gestation days 6--20 and postnatal treatment of the F1-generation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate: tumor incidence in organs other than the skin.在妊娠第6至20天用7,12 - 二甲基苯并[a]蒽对NMRI小鼠进行经胎盘起始处理，并对F1代小鼠产后用佛波酯12 - O - 十四酰佛波醇 - 13 - 乙酸酯进行处理：皮肤以外器官的肿瘤发生率
Carcinogenesis. 1981;2(11):1087-94. doi: 10.1093/carcin/2.11.1087.
7
Chemical carcinogenesis by the two-stage protocol in the skin Mastomys natalensis (Muridae) using topical initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-0-tetradecanoylphorbol-13-acetate.使用7,12-二甲基苯并(a)蒽进行局部启动和12-O-十四酰佛波醇-13-乙酸酯进行局部促进，通过两阶段方案在南非多乳鼠（鼠科）皮肤中诱导化学致癌作用。
Virchows Arch B Cell Pathol Incl Mol Pathol. 1981;38(1):13-21. doi: 10.1007/BF02892799.
8
7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoyl-phorbol-13-acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats.7,12-二甲基苯并[a]蒽/12-O-十四烷酰佛波醇-13-乙酸酯介导的雄性斯普拉格-道利大鼠皮肤肿瘤启动和促进
Carcinogenesis. 1982;3(7):785-9. doi: 10.1093/carcin/3.7.785.
9
Skin tumor formation in the European hamster (Cricetus cricetus L.) after topical initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).用7,12-二甲基苯并[a]蒽（DMBA）进行局部启动并随后用12-O-十四烷酰佛波醇-13-乙酸酯（TPA）进行促癌后，欧洲仓鼠（Cricetus cricetus L.）皮肤肿瘤的形成。
Carcinogenesis. 1984 Apr;5(4):521-4. doi: 10.1093/carcin/5.4.521.
10
Systemic two-stage carcinogenesis in the epithelium of the forestomach of mice using 7,12-dimethylbenz(a)anthracene as initiator and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate as promoter.以7,12-二甲基苯并(a)蒽为引发剂、佛波酯12-O-十四酰佛波醇-13-乙酸酯为促癌剂，在小鼠前胃上皮细胞中进行的系统性两阶段致癌作用。
Cancer Res. 1979 Apr;39(4):1293-7.

引用本文的文献

1
Prenatal susceptibility to carcinogenesis by xenobiotic substances including vinyl chloride.孕期对包括氯乙烯在内的外源性物质致癌作用的易感性。
Environ Health Perspect. 1981 Oct;41:179-88. doi: 10.1289/ehp.8141179.
2
Cocarcinogenesis and tumor promoters of the diterpene ester type as possible carcinogenic risk factors.二萜酯类的协同致癌作用及肿瘤促进剂作为可能的致癌风险因素。
J Cancer Res Clin Oncol. 1981;99(1-2):103-24. doi: 10.1007/BF00412447.
3
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.

本文引用的文献

1
[Problems of terminology and concepts in pathology of the prenatal period].[产前病理学中的术语和概念问题]
Virchows Arch Pathol Anat Physiol Klin Med. 1957;330(1):35-84. doi: 10.1007/BF00955157.
2
Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats.对怀孕大鼠单次注射乙基亚硝基脲后子代的致畸和致癌作用。
Nature. 1966 Jun 25;210(5043):1378-9. doi: 10.1038/2101378a0.
3
Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.
通过在妊娠第6至20天用7,12 - 二甲基苯并(a)蒽对怀孕小鼠进行全身启动，并在F1代出生后用佛波酯12 - 十四酰佛波醇-13 - 乙酸酯进行促进，诱导两阶段皮肤癌发生。
J Cancer Res Clin Oncol. 1980;98(3):267-75. doi: 10.1007/BF00410789.
4
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.以7,12-二甲基苯并(a)蒽（DMBA）为引发剂、12-O-十四酰佛波醇-13-乙酸酯（TPA）为促进剂，在雌性斯普拉格-道利大鼠中进行的阳性两阶段致癌作用。一项初步研究的结果。
Virchows Arch A Pathol Anat Histol. 1980;385(2):181-6. doi: 10.1007/BF00427403.
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New classes of environmental tumor promoters: indole alkaloids and polyacetates.新型环境肿瘤促进剂：吲哚生物碱和聚乙酸酯。
Environ Health Perspect. 1983 Apr;50:85-90. doi: 10.1289/ehp.835085.
6
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?在一项经过改良的两阶段贝伦布卢姆/莫特拉姆实验中，用佛波酯TPA进行产后促癌，小鼠产前X射线照射能否起到引发刺激作用？
J Cancer Res Clin Oncol. 1980;97(2):109-17. doi: 10.1007/BF00409896.
7
Keratin synthesis in normal mouse epithelia and in squamous cell carcinomas: evidence in tumors for masked mRNA species coding for high molecular weight keratin polypeptides.正常小鼠上皮组织和鳞状细胞癌中的角蛋白合成：肿瘤中存在编码高分子量角蛋白多肽的隐蔽mRNA种类的证据。
Proc Natl Acad Sci U S A. 1983 Nov;80(21):6480-4. doi: 10.1073/pnas.80.21.6480.
8
[Co-carcinogens or modulators of carcinogenesis. New aspects of the etiology of human tumors and of the molecular mechanisms of carcinogenesis].[致癌协同剂或致癌作用调节剂。人类肿瘤病因学及致癌分子机制的新进展]
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[Transplacental induction of neurogenic tumors in rabbits (author's transl)].经胎盘诱导兔神经源性肿瘤（作者译）
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Diaplacental carcinogenesis: tumor localization and tumor incidence in NMRI mice after diaplacental initiation with DMBA and urethane and postnatal promotion and the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.经胎盘致癌作用：在改良的两阶段贝伦布卢姆/莫特拉姆实验中，用二甲基苯并蒽（DMBA）和氨基甲酸乙酯进行经胎盘启动，并用佛波酯TPA进行产后促癌后，NMRI小鼠的肿瘤定位和肿瘤发生率。
Virchows Arch A Pathol Anat Histol. 1977 Nov 17;376(2):117-32. doi: 10.1007/BF00432583.
阴道腺癌。年轻女性母亲接受己烯雌酚治疗与肿瘤出现的关联。
N Engl J Med. 1971 Apr 22;284(15):878-81. doi: 10.1056/NEJM197104222841604.
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Teratogenesis-oncogenesis: a study of possible relationships.
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[Problems in transplacental carcinogenesis (author's transl)].
Geburtshilfe Frauenheilkd. 1974 Dec;34(12):1001-6.
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Systemic promoting action of phorbol in liver and lung carcinogenesis in AKR mice.佛波醇对AKR小鼠肝脏和肺癌变的全身促进作用。
Cancer Res. 1972 Oct;32(10):2259-62.
7
[Carcinogen-induced diaplacental effects in the rat. (Histological findings and the kinetics of DNA metabolism following the application of aflatoxin B1, methylazoxymethanol-acetate, and ethylnitrosourea)].[致癌物诱导的大鼠胎盘效应。（黄曲霉毒素B1、乙酸甲基偶氮甲醇和乙基亚硝基脲应用后的组织学发现及DNA代谢动力学）]
Z Krebsforsch. 1970;74(4):396-411.
8
Transplacental carcinogenesis.经胎盘致癌作用
Proc R Soc Med. 1975 Oct;68(10):655-7. doi: 10.1177/003591577506801025.
9
Transmaternal variation of the Berenblum experiment with NMRI-mice: tumour initiation with DMBA via mothers milk followed by promotion with the phorbol ester TPA.
Virchows Arch A Pathol Anat Histol. 1976 May 3;370(2):97-102. doi: 10.1007/BF00430806.