用弓形虫SAG-1蛋白进行疫苗接种对BALB/c小鼠的先天性弓形虫病具有保护作用，但对CBA/J小鼠则没有。
Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB/c mice but not in CBA/J mice.
作者信息
Letscher-Bru Valerie, Pfaff Alexander W, Abou-Bacar Ahmed, Filisetti Denis, Antoni Elisabeth, Villard Odile, Klein Jean-Paul, Candolfi Ermanno
机构信息
Institut de Parasitologie et de Pathologie Tropicale, INSERM U 392, Faculté de Médecine, Université de Strasbourg, 67000 Strasbourg, France.
出版信息
Infect Immun. 2003 Nov;71(11):6615-9. doi: 10.1128/IAI.71.11.6615-6619.2003.
Abstract
We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds. In BALB/c mice (H-2(d)), vaccination reduced the number of infected fetuses by 50% and was associated with a mixed type 1 and type 2 immunity. In CBA/J mice (H-2(k)), vaccination increased the number of infected fetuses by 50% and was associated with a predominant type 2 response. Our results indicate that the effect of vaccination with SAG1 is controlled by the genetic background of the mouse.
摘要
我们评估了用刚地弓形虫SAG1蛋白进行疫苗接种对不同遗传背景小鼠先天性弓形虫病的影响。在BALB/c小鼠（H-2(d)）中，疫苗接种使感染胎儿的数量减少了50%，并与1型和2型混合免疫相关。在CBA/J小鼠（H-2(k)）中，疫苗接种使感染胎儿的数量增加了50%，并与主要的2型反应相关。我们的结果表明，用SAG1进行疫苗接种的效果受小鼠遗传背景的控制。
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