抑制恶性疟原虫与硫酸软骨素A黏附的抗体与新生儿出生体重增加和孕周增加有关。
Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns.
作者信息
Duffy Patrick E, Fried Michal
机构信息
Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington 98109, USA.
出版信息
Infect Immun. 2003 Nov;71(11):6620-3. doi: 10.1128/IAI.71.11.6620-6623.2003.
Abstract
Antibodies that inhibit Plasmodium falciparum adhesion to the placental receptor chondroitin sulfate A are associated with a reduced risk of placental malaria, but whether these antibodies lead to improved pregnancy outcomes is unknown. We measured antiadhesion antibody levels in parturient women in western Kenya, where malaria transmission is intense. Secundigravid women with antiadhesion activity in their plasma delivered babies that were on average 398 g heavier (P = 0.019) and 2 weeks more mature (P = 0.002) than babies delivered to secundigravidas without antiadhesion activity. Our findings support the development of antiadhesion vaccines to prevent poor fetal outcomes due to pregnancy malaria.
摘要
抑制恶性疟原虫与胎盘受体硫酸软骨素A黏附的抗体与降低胎盘疟疾风险相关，但这些抗体是否能改善妊娠结局尚不清楚。我们在肯尼亚西部疟疾传播强烈的地区测量了产妇的抗黏附抗体水平。血浆中具有抗黏附活性的经产妇所分娩的婴儿，其平均体重比没有抗黏附活性的经产妇所分娩的婴儿重398克（P = 0.019），且成熟度高2周（P = 0.002）。我们的研究结果支持开发抗黏附疫苗，以预防妊娠疟疾导致的不良胎儿结局。
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