鼠伤寒沙门氏菌感染期间C3H/HeN和C3H/HeJ小鼠中Toll样受体的表达
Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection.
作者信息
Tötemeyer Sabine, Foster Neil, Kaiser Pete, Maskell Duncan J, Bryant Clare E
机构信息
Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom.
出版信息
Infect Immun. 2003 Nov;71(11):6653-7. doi: 10.1128/IAI.71.11.6653-6657.2003.
Abstract
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection. During Salmonella infections, TLR-4 is activated, leading to increased TLR-2 and decreased TLR-4 expression.
摘要
在此，我们研究了C3H/HeN小鼠（携带野生型TLR-4）和C3H/HeJ小鼠（携带突变型TLR-4）的脾脏和肝脏中Toll样受体2（TLR-2）、TLR-4和MD-2的mRNA表达，以应对沙门氏菌感染。在沙门氏菌感染期间，TLR-4被激活，导致TLR-2表达增加而TLR-4表达减少。
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