Wolgemuth Charles W, Mogilner Alexander, Oster George
Departments of Molecular & Cellular Biology and ESPM, University of California, Berkeley, CA 94720-3112, USA.
Eur Biophys J. 2004 Apr;33(2):146-58. doi: 10.1007/s00249-003-0344-5. Epub 2003 Oct 23.
We combine the physics of gels with the hydrodynamics of two-phase fluids to construct a set of equations that describe the hydration dynamics of polyelectrolyte gels. We use the model to address three problems. First, we express the effective diffusion constants for neutral and charged spherically distributed gels in terms of microscopic parameters. Second, we use the model to describe the locomotion of nematode sperm cells. Finally, we describe the swelling dynamics of polyelectrolyte gels used for drug release.
我们将凝胶物理学与两相流体的流体动力学相结合,构建了一组描述聚电解质凝胶水合动力学的方程。我们使用该模型来解决三个问题。首先,我们根据微观参数来表示中性和带电球形分布凝胶的有效扩散常数。其次,我们使用该模型来描述线虫精子细胞的运动。最后,我们描述用于药物释放的聚电解质凝胶的溶胀动力学。