Department of Biology, 622 Fordham Hall, CB3280, University of North Carolina at Chapel Hill, North Carolina 27599, USA.
Nature. 2010 Jan 28;463(7280):446-56. doi: 10.1038/nature08912.
All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10(9) base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.
所有生物，从细菌到人类，在每个细胞分裂时都面临着艰巨的任务，即复制、包装和分离多达两米（约 6x10(9) 个碱基对）的 DNA。在人类从一个受精卵发育成个体的过程中，这个任务要完成数万亿次。现在，我们已经很好地理解了 DNA 复制的策略。但是，当涉及到基因组的包装和分离时，这些机制才刚刚开始被理解，而且它们的变化程度与研究它们的生物体一样多样。
