一种用于爬行线虫精子细胞的简单一维物理模型。
A Simple 1-D Physical Model for the Crawling Nematode Sperm Cell.
作者信息
Mogilner A, Verzi D W
机构信息
Department of Mathematics, University of California, One Shields Ave., Davis, California 95616; e-mail:
出版信息
J Stat Phys. 2003 Mar 1;110(3-6):1169-1189. doi: 10.1023/A:1022153028488.
Abstract
We develop a one-dimensional physical model of the crawling movement of simple cells: The sperm of a nematode, Ascaris suum. The model is based on the assumptions that polymerization and bundling of the cytoskeletal filaments generate the force for extension at the front, and that energy stored in the gel formed from the filament bundles is subsequently used to produce the contraction that pulls the rear of the cell forward. The model combines the mechanics of protrusion and contraction with chemical control, and shows how their coupling generates stable rapid migration, so that the cell length and velocity regulate to constant values.
摘要
我们构建了一个关于简单细胞爬行运动的一维物理模型
线虫猪蛔虫的精子。该模型基于以下假设：细胞骨架细丝的聚合和捆绑产生前端伸展的力，并且由细丝束形成的凝胶中储存的能量随后用于产生收缩，从而将细胞后端向前拉动。该模型将突出和收缩的力学与化学控制相结合，并展示了它们的耦合如何产生稳定的快速迁移，从而使细胞长度和速度调节到恒定值。
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