Perez D R, Webby R J, Hoffmann E, Webster R G
Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Avian Dis. 2003;47(3 Suppl):1114-7. doi: 10.1637/0005-2086-47.s3.1114.
Chickens, quail, and other land-based birds are extensively farmed around the world. They have been recently implicated in zoonotic outbreaks of avian influenza in Hong Kong. The possibility that land-based birds could act as mixing vessels or disseminators of avian/mammalian reassortant influenza A viruses with pandemic potential has not been evaluated. In this report, we investigated whether chickens and Japanese quail are susceptible to a mammalian influenza virus (A/swine/Texas/4199-2/98 [H3N2]). This virus did not grow in chickens and replicated to low levels in Japanese quail but did not transmit. Replacing the H3 gene of this virus for one of the avian H9 viruses resulted in transmission of the avian/swine reassortant virus among quail but not among chickens. Our findings demonstrated that Japanese quail could provide an environment in which viruses like the A/swine/Texas/4199-2/98 [H3N2] virus could further reassort and generate influenza viruses with pandemic potential.
鸡、鹌鹑和其他陆基鸟类在世界各地被广泛养殖。它们最近与香港的人畜共患禽流感疫情有关。陆基鸟类是否可能成为具有大流行潜力的禽/哺乳动物重组甲型流感病毒的混合容器或传播者，这一可能性尚未得到评估。在本报告中，我们研究了鸡和日本鹌鹑是否易感染一种哺乳动物流感病毒（A/猪/得克萨斯/4199-2/98 [H3N2]）。这种病毒在鸡中不生长，在日本鹌鹑中复制水平较低，但不传播。将这种病毒的H3基因替换为一种禽H9病毒的基因，导致禽/猪重组病毒在鹌鹑之间传播，但在鸡之间不传播。我们的研究结果表明，日本鹌鹑可以提供一个环境，使像A/猪/得克萨斯/4199-2/98 [H3N2]病毒这样的病毒能够进一步重组并产生具有大流行潜力的流感病毒。
