Matrosovich M N, Krauss S, Webster R G
Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Virology. 2001 Mar 15;281(2):156-62. doi: 10.1006/viro.2000.0799.
H9N2 influenza A viruses are currently widespread in chickens, quail, and other poultry in Asia and have caused a few cases of influenza in humans. In this study, we found that H9N2 viruses from Hong Kong live bird markets have receptor specificity similar to that of human H3N2 viruses. In addition, the neuraminidase of poultry H9N2 viruses has mutations in its hemadsorbing site, a characteristic resembling that of human H2N2 and H3N2 viruses but differing from that of other avian viruses. Peculiar features of surface glycoproteins of H9N2 viruses from Hong Kong suggest an enhanced propensity for introduction into humans and emphasize the importance of poultry in the zoonotic transmission of influenza viruses.
H9N2甲型流感病毒目前在亚洲的鸡、鹌鹑及其他禽类中广泛传播，并已导致数例人类流感病例。在本研究中，我们发现来自香港活禽市场的H9N2病毒具有与人类H3N2病毒相似的受体特异性。此外，禽类H9N2病毒的神经氨酸酶在其血细胞吸附位点发生了突变，这一特征类似于人类H2N2和H3N2病毒，但与其他禽流感病毒不同。来自香港的H9N2病毒表面糖蛋白的独特特征表明其感染人类的倾向增强，并强调了禽类在流感病毒人畜共患病传播中的重要性。
