Sabri Abdelkarim, Steinberg Susan F
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Mol Cell Biochem. 2003 Sep;251(1-2):97-101.
Protein kinase C isoforms comprise a family of structurally related serine/threonine kinases that are activated by second messenger molecules formed via receptor-dependent activation of phospholipase C. Cardiomyocytes co-express multiple protein kinase C isoforms which play key roles in a spectrum of adaptive and maladaptive cardiac responses. This chapter focuses on the structural features, modes of activation, and distinct cellular actions of individual PKC isoforms in the heart. Particular emphasis is placed on progress that comes from studies in molecular models of PKC isoform overexpression or gene deletion in mice. Recent studies that distinguish the functional properties of novel PKC isoforms (PKC(delta) and PKC(epsilon)) from each other, and from the actions of the conventional PKC isoforms, and suggest that these proteins may play a particularly significant role in pathways leading to cardiac growth and/or cardioprotection also are considered.
蛋白激酶C亚型构成了一个结构相关的丝氨酸/苏氨酸激酶家族，它们通过磷脂酶C的受体依赖性激活所形成的第二信使分子而被激活。心肌细胞共表达多种蛋白激酶C亚型，这些亚型在一系列适应性和适应性不良的心脏反应中发挥关键作用。本章重点关注心脏中各个蛋白激酶C亚型的结构特征、激活模式和独特的细胞作用。特别强调了来自小鼠中蛋白激酶C亚型过表达或基因缺失分子模型研究的进展。区分新型蛋白激酶C亚型（PKCδ和PKCε）彼此之间以及与传统蛋白激酶C亚型作用不同的功能特性，并表明这些蛋白可能在导致心脏生长和/或心脏保护的途径中发挥特别重要作用的近期研究也在考虑范围内。
