Scruggs Sarah B, Wang Ding, Ping Peipei
Departments of Physiology, Medicine (Cardiology) and Bioinformatics, NIH BD2K Center of Excellence for Biomedical Computing, University of California Los Angeles, Los Angeles, CA 90095, USA.
Departments of Physiology, Medicine (Cardiology) and Bioinformatics, NIH BD2K Center of Excellence for Biomedical Computing, University of California Los Angeles, Los Angeles, CA 90095, USA.
Gene. 2016 Sep 15;590(1):90-6. doi: 10.1016/j.gene.2016.06.016. Epub 2016 Jun 13.
Protein kinase C-epsilon (PKCε) is an isoform of a large PKC family of enzymes that has a variety of functions in different cell types. Here we discuss two major roles of PKCε in cardiac muscle cells; specifically, its role in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as modulating cardiac cell energy production and metabolism by targeting cardiac mitochondria. The importance of PKCε action is described within the context of intracellular localization, as substrate selectivity and specificity is achieved through spatiotemporal targeting of PKCε. Accordingly, the role of PKCε in regulating myocardial function in physiological and pathological states has been documented in both cardioprotection and cardiac hypertrophy.
蛋白激酶C-ε（PKCε）是蛋白激酶C大家族中的一种同工型酶，在不同细胞类型中具有多种功能。在此，我们讨论PKCε在心肌细胞中的两个主要作用；具体而言，其通过靶向肌节蛋白来调节心肌收缩的作用，以及通过靶向心肌线粒体来调节心肌细胞能量产生和代谢的作用。PKCε作用的重要性在细胞内定位的背景下进行了描述，因为PKCε的底物选择性和特异性是通过其时空靶向实现的。因此，PKCε在生理和病理状态下调节心肌功能的作用已在心脏保护和心肌肥大方面得到了证实。
