Noczyńska Anna, Filipowski Henryk, Wasikowa Renata
Katedra i Klinika Endokrynologii Wieku Rozwojowego AM we Wrocławiu, Wrocław, Poland.
Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2003;9(2):89-92.
AIM OF THE STUDY was the appreciation of the body mass index (BMI) of adolescents with diabetes type 1 treated with different methods of insulin therapy as well as the correlation of the BMI with the age of the patients, duration of the diabetes therapy and with the metabolic control.
The examinations included 205 patients aged 14 to 18 years (X 16.8). The examined group consisted of 112 girls (54.5%) and 93 boys (45.5%). In all the patients the body mass index (BMI) was calculated HbA1c, total cholesterol, HDL, LDL, triglyceride the duration and method of therapy of diabetes were determined. The patients were divided in 4 groups. Group 1 and 3 included patients treated with insulin in multiple daily doses (4-5 doses). Group 1 included 49 girls, group 3-36 boys. In group 2 and 4 there were patients treated with intensive therapy with insulin analogs (Humalog, NOVO Rapid) and NPH insulin. In group 2 there were 63 girls, in group 4 -57 boys.
In the groups of boys higher statistically significant levels of HbA1c were observed in those treated with multiple daily doses (gr. 3), the body mass index was higher in boys treated with insulin analogs (gr. 4) [p<0.05, vs p<0.05].
本研究的目的是评估采用不同胰岛素治疗方法的1型糖尿病青少年的体重指数(BMI),以及BMI与患者年龄、糖尿病治疗时长和代谢控制之间的相关性。
检查对象为205名年龄在14至18岁(平均16.8岁)的患者。受检组包括112名女孩(54.5%)和93名男孩(45.5%)。所有患者均计算了体重指数(BMI),测定了糖化血红蛋白(HbA1c)、总胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯以及糖尿病的治疗时长和方法。患者被分为4组。第1组和第3组包括每日多次注射胰岛素(4 - 5次)的患者。第1组包括49名女孩,第3组包括36名男孩。第2组和第4组为采用胰岛素类似物(优泌乐、诺和锐)和中性鱼精蛋白锌胰岛素(NPH胰岛素)强化治疗的患者。第2组有63名女孩,第4组有57名男孩。
在男孩组中,每日多次注射胰岛素治疗的患者(第3组)糖化血红蛋白(HbA1c)水平具有更高的统计学显著差异,使用胰岛素类似物治疗的男孩(第4组)体重指数更高[与p<0.05相比,p<0.05]。