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糖尿病患者强化胰岛素治疗的结构化团体住院教育项目的长期影响。

Long-term impact of a structured group-based inpatient-education program for intensive insulin therapy in patients with diabetes mellitus.

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

出版信息

Wien Klin Wochenschr. 2010 Jun;122(11-12):341-5. doi: 10.1007/s00508-010-1398-x. Epub 2010 Jun 25.

Abstract

PURPOSE

Structured patient education aiming to improve self-management strategies might be beneficial for insulin-treated diabetic patients. However, in previous studies the extent of the benefit has been inconsistent in different subgroups of patients. The aim of the present study was to assess the potential benefit of a structured inpatient-education program for intensive insulin therapy according to the basal-bolus concept with particular emphasis on self-management strategies.

METHODS

We included 81 diabetic patients (59 with type 1, 14 with type 2, eight with other forms) in this retrospective longitudinal study; all had completed the training program on eight consecutive days at a university clinic between 2003 and 2005. Data assessment included HbA1c, LDL-cholesterol, HDL-cholesterol and BMI at baseline (0-15 months before the training) and after 0-5, 5-10 and 10-20 months.

RESULTS

A transient decrease of HbA1c (0.2%, 95% CI: 0.04-0.37, P = 0.017) and LDL-cholesterol levels (9.95 mg/dl, 95% CI: 2.24-17.76, P = 0.013) between baseline and the first follow-up examination was observed in the group overall. Thereafter, HbA1c and LDL-cholesterol were similar to baseline, whereas a persistent increase in HDL-cholesterol (P = 0.025) was evident in the multivariable analysis. No changes in BMI were observed. A significant type-by-time interaction (P = 0.008) in HbA1c suggests a long-term benefit in glycemic control in patients with type 2 diabetes.

CONCLUSION

A diabetes training program for intensive insulin therapy with particular emphasis on self-management skills was followed by a moderate and transient improvement of glycemic control and LDL-cholesterol and by a persistent increase in HDL-cholesterol. Long-term improvement in glycemic control was observed only in patients with type 2 diabetes.

摘要

目的

旨在改善自我管理策略的结构化患者教育可能对接受胰岛素治疗的糖尿病患者有益。然而,在以前的研究中,不同亚组患者的获益程度不一致。本研究的目的是评估根据基础-餐时胰岛素治疗概念的结构化住院患者教育计划对强化胰岛素治疗的潜在益处,特别强调自我管理策略。

方法

我们纳入了 81 例糖尿病患者(59 例 1 型,14 例 2 型,8 例其他类型)进行这项回顾性纵向研究;所有患者于 2003 年至 2005 年在一所大学诊所连续 8 天完成了培训计划。数据评估包括培训前 0-15 个月(基线)和 0-5、5-10 和 10-20 个月时的糖化血红蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL-cholesterol)、高密度脂蛋白胆固醇(HDL-cholesterol)和体重指数(BMI)。

结果

总体而言,在观察期间,HbA1c(0.2%,95%CI:0.04-0.37,P=0.017)和 LDL-cholesterol 水平(9.95mg/dl,95%CI:2.24-17.76,P=0.013)均出现一过性下降,之后与基线相似,而 HDL-cholesterol 持续升高(P=0.025)。在多变量分析中未观察到 BMI 的变化。HbA1c 的显著类型-时间交互作用(P=0.008)提示 2 型糖尿病患者的血糖控制有长期获益。

结论

强调自我管理技能的强化胰岛素治疗糖尿病培训计划后,血糖控制和 LDL-cholesterol 有适度且短暂的改善,HDL-cholesterol 持续升高。仅在 2 型糖尿病患者中观察到血糖控制的长期改善。

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