Finset Arnstein, Øverlie Inger, Holte Arne
Department of Behavioural Sciences in Medicine, University of Oslo, POB 1111 Blindern, Oslo 0317, Norway.
Psychoneuroendocrinology. 2004 Jan;29(1):49-64. doi: 10.1016/s0306-4530(02)00134-8.
To investigate the relationship between sex hormones (estradiol, testosterone, androstendione, DHEA-S) and prolactin on one hand and musculo-skeletal pain and psychological distress on the other during the menopausal transition.
Fifty-seven regularly menstruating women, who were studied over five consecutive years, who reached menopause before the fifth assessment, and did not use hormone replacement therapy were included in the study. Hormones were sampled and a questionnaire including questions on psychological distress and musculo-skeletal pain were administered at the five points of assessment. Data on last year before menopause (T1), first (T2) and second (T3) year after menopause are reported.
DHEA-S, but neither testosterone nor androstendione, was inversely related to distress and pain. Pain contributed to the variance of DHEA-S over the menopausal transition, whereas DHEA-S levels did not predict pain or distress when baseline levels were controlled for. Prolactin was at T1 and T2 positively associated with distress and at T2 positively associated with musculo-skeletal pain. Musculo-skeletal pain pre-menopause was significantly related to estradiol.
DHEA-S was negatively associated, and prolactin positively associated with musculo-skeletal pain and psychological distress. Whereas post-menopause DHEA-S levels were influenced by pain scores, no significant effect of pre-menopause hormones on post-menopause pain and distress was found.
探讨绝经过渡期间性激素（雌二醇、睾酮、雄烯二酮、硫酸脱氢表雄酮）和催乳素一方面与肌肉骨骼疼痛和心理困扰另一方面之间的关系。
本研究纳入了57名月经规律的女性，她们连续5年接受研究，在第五次评估前绝经且未使用激素替代疗法。在五个评估点采集激素样本，并发放一份包含心理困扰和肌肉骨骼疼痛问题的问卷。报告绝经前最后一年（T1）、绝经后第一年（T2）和第二年（T3）的数据。
硫酸脱氢表雄酮与困扰和疼痛呈负相关，而睾酮和雄烯二酮则不然。在绝经过渡期间，疼痛导致了硫酸脱氢表雄酮水平的变化，而在控制基线水平后，硫酸脱氢表雄酮水平并不能预测疼痛或困扰。催乳素在T1和T2时与困扰呈正相关，在T2时与肌肉骨骼疼痛呈正相关。绝经前的肌肉骨骼疼痛与雌二醇显著相关。
硫酸脱氢表雄酮与肌肉骨骼疼痛和心理困扰呈负相关，催乳素与之呈正相关。绝经后硫酸脱氢表雄酮水平受疼痛评分影响，而未发现绝经前激素对绝经后疼痛和困扰有显著影响。
