Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, Japan.
Maturitas. 2012 Nov;73(3):255-60. doi: 10.1016/j.maturitas.2012.08.003. Epub 2012 Aug 28.
We examined (1) the change in circulating adiponectin in women during the menopausal transition and (2) the associations of adiponectin levels with estrogen, androgen and sex hormone-binding globulin (SHBG) in women during the menopausal transition.
We conducted a cross-sectional study in 235 healthy women and divided them into 7 stages by menstrual regularity and follicle-stimulating hormone (FSH) level. Serum levels of adiponectin, estradiol, total testosterone, dehydroepiandrosterone-sulfate (DHEA-S) and SHBG were measured. Levels of free and bioavailable testosterone were calculated by using total testosterone, albumin and SHBG.
Serum adiponectin levels showed a U-curve, levels being low in early and late menopausal transition and gradually becoming higher after menopause. Adiponectin levels were negatively correlated with levels of free testosterone, bioavailable testosterone and DHEA-S and were positively correlated with SHBG in postmenopausal women for whom more than 1 year had passed since menopause. Adiponectin level was not correlated with estradiol level.
Circulating adiponectin level shows a U-curve during the menopausal transition and adiponectin level is associated with levels of free and bioavailable testosterone and DHEA-S in postmenopause.
我们考察了（1）女性在绝经过渡期间循环脂联素的变化，以及（2）在绝经过渡期间，脂联素水平与雌激素、雄激素和性激素结合球蛋白（SHBG）在女性中的相关性。
我们对 235 名健康女性进行了一项横断面研究，并根据月经规律和卵泡刺激素（FSH）水平将她们分为 7 个阶段。测量血清脂联素、雌二醇、总睾酮、硫酸脱氢表雄酮（DHEA-S）和 SHBG 水平。通过总睾酮、白蛋白和 SHBG 计算游离睾酮和生物可利用睾酮的水平。
血清脂联素水平呈 U 型曲线，在绝经早期和晚期水平较低，绝经后逐渐升高。在绝经后至少 1 年的女性中，脂联素水平与游离睾酮、生物可利用睾酮和 DHEA-S 水平呈负相关，与 SHBG 水平呈正相关。脂联素水平与雌二醇水平无关。
循环脂联素水平在绝经过渡期间呈 U 型曲线，绝经后脂联素水平与游离睾酮和生物可利用睾酮及 DHEA-S 水平相关。
