Allikmets L Kh, Zharkovskiĭ A m, Vasar E E
Biull Eksp Biol Med. 1977 Jul;84(7):51-3.
The effect of simultaneous injections of apomorphine and l-DOPA on stereotypy, aggressiveness, on the exploratory motor activity, the threshold of emotional reactivity and aggressiveness elicited by painful electrical stimulation was studied in experiments on male albino rats. When injected separately, in control experiments, both compounds had similar effects on the exploratory-motor activity and the emotional behaviour, but when injected simultaneously in various doses a distinct antagonism between l-DOPA and apomorphine, according to all the behaviour tests, was noted (a decrease of sterotypy, aggressiveness and emotional reactivity). Against the background of l-DOPA apomorphine (5 mg/kg) increased the dopamine content in the forebrain and in the diencephalon even more. It is suggested that the increased level of the functionally active mediator suppressed the activity of postsynaptic receptors sensitive to it.
在雄性白化大鼠实验中，研究了同时注射阿扑吗啡和左旋多巴对刻板行为、攻击性、探索性运动活动、由疼痛电刺激引发的情绪反应阈值和攻击性的影响。在对照实验中，单独注射时，两种化合物对探索性运动活动和情绪行为有相似的影响，但当以不同剂量同时注射时，根据所有行为测试，观察到左旋多巴和阿扑吗啡之间存在明显的拮抗作用（刻板行为、攻击性和情绪反应降低）。在左旋多巴的背景下，阿扑吗啡（5毫克/千克）使前脑和间脑中的多巴胺含量增加得更多。有人认为，功能活性介质水平的升高抑制了对其敏感的突触后受体的活性。
