Kudina N H, Andriĭchuk T R, Tsudzevych B O
Taras Shevchenko Kyiv National University, Ukraine.
Ukr Biokhim Zh (1999). 2003 Mar-Apr;75(2):109-12.
It has been established, that the total X-ray irradiation of animals takes influence upon the functional activity of key enzymes of adenine nucleotides metabolism: adenylatekinase, AMP deaminase, 5'-nucleotidase, adenosine deaminase and purine nucleoside phosphorylase in rat's thymocytes. The increase of activity of the investigated enzymes is observed in our experiment, except 5'-nucleotidase, which activity is authentically decreasing after irradiation (1.0 and 7.78 Gy). The injection of the preparation riboxine to experimental animals 15 min prior to the exposure has normalized the purine exchange enzymes activity.
已经确定，对动物进行全身X射线照射会影响大鼠胸腺细胞中腺嘌呤核苷酸代谢关键酶的功能活性：腺苷酸激酶、AMP脱氨酶、5'-核苷酸酶、腺苷脱氨酶和嘌呤核苷磷酸化酶。在我们的实验中，除5'-核苷酸酶外，所研究酶的活性均有所增加，5'-核苷酸酶的活性在照射（1.0和7.78 Gy）后确实下降。在照射前15分钟给实验动物注射制剂核糖核酸已使嘌呤交换酶的活性恢复正常。
