[Effects of corticosteroid on eosinophils and expression of transforming growth factor beta 1 in nasal polyps].
作者信息
Tao Zezhang, Kong Yonggang, Xiao Bokui, Ye Linfeng, Wu Xiuzhi
机构信息
Department of Otolaryngology-Head and Neck Surgery, People's Hospital of Wuhan University, Wuhan 430060.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 Aug;17(8):474-5.
OBJECTIVE
To observe the effects of systemic steroids on the infiltration of eosinophils and the expression of TGF beta 1 in nasal polyps.
METHOD
The SP immunohistochemical methods were applied to explore the expression of TGF beta 1 in nasal polyps before and after corticosteroids use; the optical density of positive cells in mucosal epithelia, eosinophils, glandular epithelium, vascular endothelial, matrix and mucous membrane was measured by using HPIAS-1,000 image-conduct system.
RESULT
The expression of TGF beta 1 was positive in nasal polyps. The number of eosinophils and the expression of TGF beta 1 was significantly reduced in nasal polyps after treated with corticosteroids compared with pre-treated.
CONCLUSION
The effects of systemical steroid use on the nasal polyps may depend on decreasing the infiltration of eosinophils and the expression of TGF beta 1.
Zotero 插件