Ito Kunihiko, Hashimoto Kenichi, Ogata Hideo
Research Division, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24, Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan.
Kekkaku. 2003 Sep;78(9):587-90.
To screen effective useful drugs for disease due to M. abscessus, we determined MIC of 3 cephems [ceftazidime (CAZ), cefoxitin (CFX), flomoxef (FMOX)] and 3 carbapenems [imipenem (IPM), panipenem (PAPM), meropenem (MEPM)] for 8 strains of clinically isolated M. abscessus by micro-dilution method using MGIT system. In all the 8 strains, MICs of CAZ are higher than 32 micrograms/ml. MIC50, MIC90, MIC range of CFX are 32 micrograms/ml, > 32 micrograms/ml and 16- > 32 micrograms/ml respectively, and for FMOX, 16 micrograms/ml, 32 micrograms/ml and 16-32 micrograms/ml; for IPM, 8 micrograms/ml, 16 micrograms/ml and 8-16 micrograms/ml; for PAPM, 4 micrograms/ml, 16 micrograms/ml and 4-16 micrograms/ml; for MEPM, 8 micrograms/ml, 16 micrograms/ml and 8-16 micrograms/ml. From this study, it is concluded that FMOX, IPM, PAPM and MEPM can be clinically useful drugs in the treatment of the disease due to M. abscessus.
为筛选治疗脓肿分枝杆菌所致疾病的有效药物，我们采用MGIT系统通过微量稀释法测定了8株临床分离的脓肿分枝杆菌对3种头孢菌素类药物[头孢他啶（CAZ）、头孢西丁（CFX）、氟氧头孢（FMOX）]和3种碳青霉烯类药物[亚胺培南（IPM）、帕尼培南（PAPM）、美罗培南（MEPM）]的最低抑菌浓度（MIC）。在所有8株菌株中，CAZ的MIC均高于32微克/毫升。CFX的MIC50、MIC90、MIC范围分别为32微克/毫升、>32微克/毫升和16->32微克/毫升，FMOX的分别为16微克/毫升、32微克/毫升和16-32微克/毫升；IPM的分别为8微克/毫升、16微克/毫升和8-16微克/毫升；PAPM的分别为4微克/毫升、16微克/毫升和4-16微克/毫升；MEPM的分别为8微克/毫升、16微克/毫升和8-16微克/毫升。从本研究得出结论，FMOX、IPM、PAPM和MEPM可作为治疗脓肿分枝杆菌所致疾病的临床有效药物。
