Drobin Dan, Hahn Robert G
Department of Anaesthesia, South Hospital, S-118 83 Stockholm, Sweden.
Clin Sci (Lond). 2004 Mar;106(3):307-13. doi: 10.1042/CS20030349.
Pre-eclampsia (PE) is a disease of pregnancy associated with peripheral oedema and hypovolaemia, but few details are known about how women with PE handle a volume load of crystalloid fluid compared with healthy pregnant women. To study this issue, Ringer's acetate solution (12.5 ml/kg of body weight) was given by intravenous infusion over 30 min to eight women with PE and to eight healthy pregnant women matched with respect to gestational week (mean, 34 weeks). Venous blood was sampled and excreted urine was collected over 90 min to study the time course of the volume expansion by means of volume kinetic analysis. The results show that the size of the central body fluid space expanded by the infused fluid was smaller in PE (mean, 2940 ml compared with 4240 ml respectively; P<0.04), and the clearance constants for distribution (100 ml/min compared with 43 ml/min; P<0.04) and elimination (125 ml/min compared with 36 ml/min; P<0.02) were higher in the women with PE than in the controls. Less excess volume accumulated in the central body fluid space in the presence of PE, whereas the rates of distribution and elimination were higher during and for 15 min after the infusion. It is concluded that Ringer's acetate solution fluid is both distributed and eliminated faster in women with PE than in matched pregnant controls.
子痫前期（PE）是一种与外周水肿和血容量不足相关的妊娠疾病，但与健康孕妇相比，关于PE患者如何处理晶体液容量负荷的细节知之甚少。为研究此问题，对8名单胎妊娠合并子痫前期患者和8名孕周匹配（平均34周）的健康孕妇静脉输注复方醋酸林格注射液（12.5 ml/kg体重），输注时间为30分钟。在90分钟内采集静脉血样并收集尿液，通过容量动力学分析研究容量扩张的时间过程。结果显示，子痫前期患者输注液体后中心体液空间的扩张幅度较小（分别为2940 ml和4240 ml；P<0.04），子痫前期患者的分布清除常数（分别为100 ml/min和43 ml/min；P<0.04）和消除清除常数（分别为125 ml/min和36 ml/min；P<0.02）高于对照组。子痫前期患者中心体液空间中积聚的过量液体较少，而输注期间及输注后15分钟内的分布和消除速率较高。由此得出结论，复方醋酸林格注射液在子痫前期患者中的分布和消除速度均快于匹配的正常妊娠对照组。
