Choi Kyung-Chul, Auersperg Nelly, Leung Peter C K
Department of Obstetrics and Gynaecology, BC Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5.
Reprod Biol Endocrinol. 2003 Oct 7;1:71. doi: 10.1186/1477-7827-1-71.
Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells. Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer. In this article, an activation of the MAPK signaling cascade by several key reproductive hormones and growth factors in epithelial ovarian cancer is reviewed.
丝裂原活化蛋白激酶（MAPKs）是一类丝氨酸/苏氨酸激酶，可响应多种细胞外刺激而被激活，并介导从细胞表面到细胞核的信号转导。已有研究表明，在卵巢表面上皮细胞中，MAPKs可被包括化疗药物、生长因子和生殖激素在内的外部刺激激活。因此，MAPK信号通路可能在卵巢癌中响应这些外部刺激调节细胞增殖、存活和凋亡方面发挥重要作用。本文综述了上皮性卵巢癌中几种关键生殖激素和生长因子对MAPK信号级联的激活作用。
