Kopp A F, Laniado M, Aicher K P, Grönewäller E F, Claussen C D
Radiologische Klinik, Abteilung für Radiologische Diagnostik, Eberhard-Karls-Universität, Tübingen.
Rofo. 1992 Dec;157(6):539-47. doi: 10.1055/s-2008-1033059.
Twenty patients with focal liver lesions (18 metastases, 1 hepatocellular carcinoma, 1 cholangiocarcinoma) were given manganese DPDP as part of a multicentric phase II study of paramagnetic hepatobiliary MR contrast media. 5 mumol/kg manganese DPDP were injected into 10 patients in a concentration of 50 mumol/ml or 10 mumol/ml (3 ml/min). Blood pressure, pulse rate, ECG, respiratory rate, body temperature, blood and serum parameters and the patients' subjective feelings were recorded. MRI was performed with 1.5 T using T1- and T2-weighted sequences. 6 patients reported 8 side effects (flushing, feeling of warmth, metallic taste); 7 of these were produced by the 50 mumol concentration. Two hours after injection there was a significant reduction in alkaline phosphatase which was no longer present after 24 hours. On T1-weighted images manganese DPDP resulted in marked improvement in the contrast difference between the lesions and the liver parenchyma which resulted in a marked increase in the signal to noise ratio. Comparing the two concentrations, better results were obtained by the lower concentration. Extrahepatic uptake was found in the gallbladder, duodenum, pancreas, kidneys, gastric mucosa and myocardium. Manganese DPDP in a concentration of 10 mumol/ml and a dose of 5 mumol/kg is a well tolerated contrast medium which improves the demonstration of focal liver lesions in view of its distribution and uptake. The mechanisms for the transitory side effects require further studies.
20例有局灶性肝病变的患者（18例转移瘤、1例肝细胞癌、1例胆管癌）接受了锰福地吡作为顺磁性肝胆磁共振造影剂多中心II期研究的一部分。以50μmol/ml或10μmol/ml的浓度（3ml/分钟）给10例患者注射5μmol/kg锰福地吡。记录血压、脉搏率、心电图、呼吸频率、体温、血液和血清参数以及患者的主观感受。使用1.5T磁共振成像仪，采用T1加权和T2加权序列进行检查。6例患者报告了8次副作用（脸红、发热感、金属味）；其中7次是由50μmol浓度引起的。注射后2小时碱性磷酸酶显著降低，24小时后不再存在。在T1加权图像上，锰福地吡使病变与肝实质之间的对比差异显著改善，导致信噪比显著提高。比较两种浓度，较低浓度获得了更好的结果。在胆囊、十二指肠、胰腺、肾脏、胃黏膜和心肌中发现了肝外摄取。浓度为10μmol/ml、剂量为5μmol/kg的锰福地吡是一种耐受性良好的造影剂，鉴于其分布和摄取情况，可改善局灶性肝病变的显示。短暂副作用的机制需要进一步研究。
