Rofsky N M, Earls J P
Department of Magnetic Resonance Imaging, New York University Medical Center, New York, USA.
Magn Reson Imaging Clin N Am. 1996 Feb;4(1):73-85.
Mangafodipir trisodium (Mn-DPDP) is one of several recently developed targeted hepatobiliary agents. Contrast-to-noise measurements have shown favorable results for Mn-DPDP-enhanced MR as compared with nonenhanced T1- and T2-weighted images. An improved capability for lesion detection and the ability to characterize tumors of hepatocellular origin have been demonstrated. The prolonged enhancement obtained with Mn-DPDP provides an extended window of time during which effective contrast is maintained as compared with traditional extracellular contrast agents. This report details the experimental and initial clinical experience with Mn-DPDP-enhanced MR imaging of the abdomen.
锰福地匹三钠（Mn-DPDP）是近期研发的几种靶向肝胆造影剂之一。对比噪声测量结果显示，与未增强的T1加权和T2加权图像相比，Mn-DPDP增强磁共振成像（MR）效果良好。已证实其在病变检测能力方面有所提升，且能够对肝细胞源性肿瘤进行特征描述。与传统细胞外造影剂相比，Mn-DPDP产生的延长强化提供了一个更长的时间窗，在此期间可维持有效的对比。本报告详细介绍了Mn-DPDP增强腹部MR成像的实验及初步临床经验。
