Stemberga V, Dobi-Babić R, Bosnar A, Cuculić D, Fuckar D, Stifter S, Kusec R, Marusić-Vrsalović M, Jonjić N
Department of Forensic Medicine, Medical Faculty, University of Rijeka, Croatia.
Hematol Oncol. 2003 Sep;21(3):109-14. doi: 10.1002/hon.713.
A case of primary non-Hodgkin lymphoma of the right humerus which occurred in a 21-year-old male patient after an impact to the right shoulder in a car accident in July 1983 is described. Seventeen years after the injury, due to a civil lawsuit, the biopsy material was revised. Immunohistochemical analysis showed CD20 and CD79a positivity on large pleomorphic cells, while small reactive lymphocytes were CD3, Bcl-2 and CD20 positive. Molecular analysis carried out with PCR revealed a monoclonal B-lymphocyte population. The diagnosis of diffuse large peripheral B cell lymphoma of the bone was confirmed. The present case concurs with the literature on primary bone lymphoma, in which the diagnostic problem, trauma-related presentation and an excellent prognosis of malignant tumour are emphasized.
本文描述了一例原发性右肱骨非霍奇金淋巴瘤病例，该病例发生于一名21岁男性患者，1983年7月其在一场车祸中右肩部受到撞击。受伤17年后，因一场民事诉讼，对活检材料进行了复查。免疫组织化学分析显示，大的多形性细胞呈CD20和CD79a阳性，而小的反应性淋巴细胞呈CD3、Bcl-2和CD20阳性。采用聚合酶链反应（PCR）进行的分子分析显示存在单克隆B淋巴细胞群。骨弥漫性大外周B细胞淋巴瘤的诊断得以证实。本病例与原发性骨淋巴瘤的文献报道相符，其中强调了诊断问题、与创伤相关的表现以及恶性肿瘤的良好预后。
