van der Kleij Desiree, Yazdanbakhsh Maria
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Eur J Immunol. 2003 Nov;33(11):2953-63. doi: 10.1002/eji.200324340.
Inflammatory diseases such as asthma and diabetes are rising in industrialized countries and the modern lifestyle that is associated with lower exposure to microbes has been held responsible for the increasing prevalence of these diseases. Several studies have shown an inverse association between pathogen-exposure and allergy or autoimmunity. The mechanisms behind such protective effects have been investigated at the epidemiological, cellular and molecular level and have provided data on the ability of lipids either derived directly from pathogens or up-regulated as a result of an infection to down-regulate immune responses and thereby control inflammatory diseases. In this mini-review, recent findings and new concepts relating to the immunosuppressive effects of endogenous lipids and those encountered upon exposure to bacteria, protozoa and particularly helminths are discussed. The overview focuses on the modulation of interactions between the antigen-presenting compartment and T cells to start an anti-inflammatory "program" with potential to regulate disease processes.
在工业化国家，诸如哮喘和糖尿病等炎症性疾病的发病率正在上升，与较低微生物接触水平相关的现代生活方式被认为是这些疾病患病率增加的原因。多项研究表明病原体接触与过敏或自身免疫之间存在负相关。已经在流行病学、细胞和分子水平上研究了这种保护作用背后的机制，并提供了有关直接源自病原体或因感染而上调的脂质下调免疫反应从而控制炎症性疾病能力的数据。在本综述中，讨论了与内源性脂质以及接触细菌、原生动物特别是蠕虫后所产生脂质的免疫抑制作用相关的最新发现和新概念。综述重点关注对抗抗原呈递区室与T细胞之间的相互作用进行调节，以启动一个具有调节疾病进程潜力的抗炎“程序”。
