hMSH2基因多态性（gIVS 12-6T→C）与日本人群非霍奇金淋巴瘤风险

Polymorphism in the hMSH2 gene (gIVS 12-6T-->C) and risk of non-Hodgkin lymphoma in a Japanese population.

作者信息

Hishida Asahi, Matsuo Keitaro, Hamajima Nobuyuki, Ito Hidemi, Ogura Michinori, Kagami Yoshitoyo, Taji Hirofumi, Morishima Yasuo, Emi Nobuhiko, Tajima Kazuo

机构信息

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, 464-8681, Nagoya, Japan.

出版信息

Cancer Genet Cytogenet. 2003 Nov;147(1):71-4. doi: 10.1016/s0165-4608(03)00185-7.

DOI:10.1016/s0165-4608(03)00185-7

PMID:14580774

Abstract

We conducted a hospital-based prevalent case-control study in a Japanese population (cases=103, controls=487) to ascertain the previous report about the association between the polymorphism in exon 13 of the hMSH2 gene (gIVS 12-6T-->C) and the risk of non-Hodgkin lymphoma in an Ecuadorian population. When the TT genotype was defined as the reference, none of the CT genotypes (OR=1.52; 95% CI, 0.97-2.37), CC genotypes (OR=1.06, 95% CI, 0.44-2.54), or CT and CC genotypes combined together (OR=1.44, 95% CI, 0.94-2.23) demonstrated significant OR. Further investigations with sufficiently larger populations and in other ethnicities are required to verify this association.

摘要

我们在日本人群中开展了一项基于医院的现患病例对照研究（病例 = 103，对照 = 487），以证实先前关于hMSH2基因第13外显子多态性（gIVS 12 - 6T→C）与厄瓜多尔人群中非霍奇金淋巴瘤风险之间关联的报告。当将TT基因型定义为参照时，CT基因型（比值比 = 1.52；95%置信区间，0.97 - 2.37）、CC基因型（比值比 = 1.06，95%置信区间，0.44 - 2.54）或CT和CC基因型合并在一起（比值比 = 1.44，95%置信区间，0.94 - 2.23）均未显示出显著的比值比。需要在足够大的人群以及其他种族中进行进一步研究，以验证这种关联。