Hishida Asahi, Matsuo Keitaro, Hamajima Nobuyuki, Ito Hidemi, Ogura Michinori, Kagami Yoshitoyo, Taji Hirofumi, Morishima Yasuo, Emi Nobuhiko, Tajima Kazuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, 464-8681, Nagoya, Japan.
Cancer Genet Cytogenet. 2003 Nov;147(1):71-4. doi: 10.1016/s0165-4608(03)00185-7.
We conducted a hospital-based prevalent case-control study in a Japanese population (cases=103, controls=487) to ascertain the previous report about the association between the polymorphism in exon 13 of the hMSH2 gene (gIVS 12-6T-->C) and the risk of non-Hodgkin lymphoma in an Ecuadorian population. When the TT genotype was defined as the reference, none of the CT genotypes (OR=1.52; 95% CI, 0.97-2.37), CC genotypes (OR=1.06, 95% CI, 0.44-2.54), or CT and CC genotypes combined together (OR=1.44, 95% CI, 0.94-2.23) demonstrated significant OR. Further investigations with sufficiently larger populations and in other ethnicities are required to verify this association.
我们在日本人群中开展了一项基于医院的现患病例对照研究（病例 = 103，对照 = 487），以证实先前关于hMSH2基因第13外显子多态性（gIVS 12 - 6T→C）与厄瓜多尔人群中非霍奇金淋巴瘤风险之间关联的报告。当将TT基因型定义为参照时，CT基因型（比值比 = 1.52；95%置信区间，0.97 - 2.37）、CC基因型（比值比 = 1.06，95%置信区间，0.44 - 2.54）或CT和CC基因型合并在一起（比值比 = 1.44，95%置信区间，0.94 - 2.23）均未显示出显著的比值比。需要在足够大的人群以及其他种族中进行进一步研究，以验证这种关联。
